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butein

Known as: 2',3,4,4'-Tetrahydroxy-chalcone, 2',3,4,4'-tetrahydroxychalcone, 2',4',3,4-tetrahydroxychalcone 
A flavonoid obtained from the seed of Cyclopia subternata. It is a specific protein tyrosine kinase inhibitor that induces apoptosis. (NCI)
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Chalcones
Receptor Tyrosine Kinase Inhibition

Papers overview

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Review
2016
Review
2016
Butein and Its Role in Chronic Diseases.
Natural compounds isolated from various plant sources have been used for therapeutic purpose for centuries. These compounds have… 
2015
2015
Butein, a tetrahydroxychalcone, suppresses pro-inflammatory responses in HaCaT keratinocytes
Up-regulation of cell adhesion molecules and proinflammatory cytokines contributes to enhanced monocyte adhesiveness and… 
2015
2015
Antiplatelet effects of Rhus verniciflua stokes heartwood and its active constituents--fisetin, butein, and sulfuretin--in rats.
Rhus verniciflua stokes (RVS) is known to promote blood circulation by preventing blood stasis, although the active ingredients… 
2012
2012
Butein Induces Apoptosis in Human Uveal Melanoma Cells Through Mitochondrial Apoptosis Pathway
Purpose: To study the cytotoxic effects and related signaling pathways of butein on human uveal melanoma cells in vitro… 
Highly Cited
2011
Highly Cited
2011
Butein inhibits the migration and invasion of SK-HEP-1 human hepatocarcinoma cells through suppressing the ERK, JNK, p38, and uPA signaling multiple pathways.
Liver cancer is one of the most commonly diagnosed cancers and the leading cause of death in human populations. Butein, a… 
2008
2008
Butein sensitizes human leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL)
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) therapy is frequently encountered, requiring… 
Highly Cited
2006
Highly Cited
2006
Rhus verniciflua stokes extract: radical scavenging activities and protective effects on H2O2-induced cytotoxicity in macrophage RAW 264.7 cell lines.
The goal of this study was to determine the effects of Rhus verniciflua stokes (RVS) on the radical scavenging activities and… 
1996
1996
Butein ameliorates experimental anti-glomerular basement membrane (GBM) antibody-associated glomerulonephritis in rats (1).
Effects of butein on crescentic-type anti-glomerular basement membrane (GBM) nephritis in rats were investigated. When rats were… 
1983
1983
Metabolism and excretion of butein, 2',3,4-trihydroxychalcone, 3-O-methylbutein, 4-O-methylbutein and 2',4',4-trihydroxychalcone in the rat.
Butein (2',3,4,4'-tetrahydroxychalcone) and 2',3,4-trihydroxychalcone, following administration to bile-duct-cannulated rats… 
1956
1956
The flavonoid glycosides of Dahlia variabilis. II. Glycosides of yellow varieties Pius IX and Coton.
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