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bunitrolol

Known as: Benzonitrile, 2-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)- 
National Institutes of Health

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2 relations

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Ko 1366

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Propanolamines

Papers overview

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2001
2001
Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol.
Repetitive administration of propranolol (PL) in rats decreases the activities of cytochrome P450 (CYP) 2D enzyme(s) in hepatic… 
1999
1999
Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.
The enantioselectivity of 4-hydroxylation of bunitrolol (BTL), a beta-adrenoceptor blocking drug, was studied in microsomes from… 
Highly Cited
1998
Highly Cited
1998
Molecular basis of the Dark Agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2.
The Dark Agouti rat has been proposed as a model for the human debrisoquine 4-hydroxylase polymorphism. Earlier studies suggested… 
1997
1997
Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes.
Cytochrome P450 enzymes belonging to the CYP2D subfamily have been shown to be one of determinants of the polymorphic drug… 
1996
1996
Stereoselectivity in bunitrolol 4-hydroxylation in liver microsomes from marmosets and Japanese monkeys.
The stereoselectivity in 4-hydroxylation of bunitrolol (BTL), a beta-adrenoreceptor blocking agent, was examined in liver… 
1995
1995
Oxidative metabolism of bunitrolol by complementary DNA-expressed human cytochrome P450 isozymes in a human hepatoma cell line (Hep G2) using recombinant vaccinia virus.
We examined the oxidative metabolism of a beta-blocker bunitrolol (BTL) by 10 human cytochromes P450 (CYP) (1A2, 2A6, 2B6, 2C8… 
1994
1994
Involvement of a cytochrome P4502D subfamily in human liver microsomal bunitrolol 4-hydroxylation.
The oxidative metabolism of bunitrolol, an adrenergic beta-receptor antagonist was examined in human liver microsomes fortified… 
1992
1992
Purification and characterization of a cytochrome P-450 isozyme catalyzing bunitrolol 4-hydroxylation in liver microsomes of male rats.
A cytochrome P-450 isozyme, P-450 bunitrolol (BTL), catalyzing bunitrolol 4-hydroxylation was partially purified from liver… 
1991
1991
Vascular effects of betaxolol, a cardioselective beta-adrenoceptor antagonist, in isolated rat arteries.
The effects of betaxolol on isolated rat arteries and the modes of action were investigated. Betaxolol (10(-5)-10(-3) M) relaxed… 
Highly Cited
1988
Highly Cited
1988
Stereospecificity of beta adrenergic antagonists: R-enantiomers show increased selectivity for beta-2 receptors in ciliary process.
The (+)-stereoisomers of arylethanolamine beta adrenergic agonists and antagonists are usually much less active in biological… 
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