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bunitrolol

Known as: Benzonitrile, 2-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)- 
National Institutes of Health

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Propanolamines

Papers overview

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2001
2001
Functional evaluation of cytochrome P450 2D6 with Gly42Arg substitution expressed in Saccharomyces cerevisiae.
A single amino acid-substituted mutant protein, CYP2D6 (G42R) was expressed in Saccharomyces cerevisiae and its enzymatic… 
2001
2001
Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol.
Repetitive administration of propranolol (PL) in rats decreases the activities of cytochrome P450 (CYP) 2D enzyme(s) in hepatic… 
1999
1999
Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.
The enantioselectivity of 4-hydroxylation of bunitrolol (BTL), a beta-adrenoceptor blocking drug, was studied in microsomes from… 
1996
1996
Stereoselectivity in bunitrolol 4-hydroxylation in liver microsomes from marmosets and Japanese monkeys.
The stereoselectivity in 4-hydroxylation of bunitrolol (BTL), a beta-adrenoreceptor blocking agent, was examined in liver… 
1995
1995
Oxidative metabolism of bunitrolol by complementary DNA-expressed human cytochrome P450 isozymes in a human hepatoma cell line (Hep G2) using recombinant vaccinia virus.
We examined the oxidative metabolism of a beta-blocker bunitrolol (BTL) by 10 human cytochromes P450 (CYP) (1A2, 2A6, 2B6, 2C8… 
1994
1994
Involvement of a cytochrome P4502D subfamily in human liver microsomal bunitrolol 4-hydroxylation.
The oxidative metabolism of bunitrolol, an adrenergic beta-receptor antagonist was examined in human liver microsomes fortified… 
1994
1994
Development of a high-performance liquid chromatographic method for the analysis of enatiomer/enantiomer interaction in oxidative metabolism of bunitrolol in rat liver microsomes.
A high-performance liquid chromatographic method for the assay of enantiomeric 4-hydroxybunitrolol (4-OH-BTL) formed from racemic… 
1991
1991
Vascular effects of betaxolol, a cardioselective beta-adrenoceptor antagonist, in isolated rat arteries.
The effects of betaxolol on isolated rat arteries and the modes of action were investigated. Betaxolol (10(-5)-10(-3) M) relaxed… 
1987
1987
Effects of bunitrolol on adrenergic and serotonergic receptors.
To assess the importance of anti-adrenergic and anti-serotonergic activities of bunitrolol for its efficacy as an… 
1979
1979
Long‐term Hemodynamic Effects of Bunitrolol at Rest and During Exercise in Essential Hypertension
The long-term hemodynamic effects of a new beta-adrenoceptor blocker, bunitrolol, were evaluated in 11 men with untreated… 
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