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bucolome

Known as: 1-cyclohexyl-5-butylbarbituric acid, 2,4,6(1H,3H,5H)-Pyrimidnetrione, 5-butyl-1-cyclohexyl- 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

BarbitalBarbiturates

Narrower (1)

Paramidine

Papers overview

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2011
2011
Effects of combination therapy with warfarin and bucolome for anticoagulation in patients with atrial fibrillation.
BACKGROUND Bucolome, a nonsteroidal antiinflammatory drug, enhances the effects of warfarin. In the present study, the effects of… 
2008
2008
The effect of bucolome, a CYP2C9 inhibitor, on the pharmacokinetics of losartan.
Losartan, a selective angiotensin receptor antagonist, is mainly metabolized by CYP2C9 to an active carboxylic acid, E3174, which… 
2005
2005
BUCOLOME, A POTENT BINDING INHIBITOR FOR FUROSEMIDE, ALTERS THE PHARMACOKINETICS AND DIURETIC EFFECT OF FUROSEMIDE: POTENTIAL FOR USE OF BUCOLOME TO RESTORE DIURETIC RESPONSE IN NEPHROTIC SYNDROME
To determine whether bucolome (5-n-butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine), a nonsteroidal anti-inflammatory agent… 
2001
2001
The Stereoselective Effects of Bucolome on the Pharmacokinetics and Pharmacodynamics of Racemic Warfarin
The objective of this study was to investigate the stereoselective influence of bucolome on the pharmacokinetics and… 
1999
1999
Pharmacokinetic interaction between warfarin and a uricosuric agent, bucolome: application of In vitro approaches to predicting In vivo reduction of (S)-warfarin clearance.
A uricosuric agent, bucolome, has been shown to intensify the anticoagulant effect of warfarin. The aims of the present study… 
1985
1985
Bucolome N-glucuronide: purification and identification of a major metabolite of bucolome in rat bile.
A biliary metabolite of bucolome in rat was isolated and purified by column chromatography. The metabolite has been identified as… 
1982
1982
Increased Nervous System‐Specific Enolases in Rat Plasma and Cerebrospinal Fluid in Bilirubin Encephalopathy Detected by an Enzyme Immunoassay
Abstract: Three forms of enolase isozymes (αα, αγ, and γγ), including nervous system‐specific forms, were measured in the… 
1978
1978
Danger of bucolome in infants with hyperbilirubinaemia. Experimental evidence.
Effects of bucolome on congenitally jaundiced Gunn rats were examined. Plasma total bilirubin level fell immediately after a… 
1977
1977
Bucolome in prevention of hyperbilirubinaemia in preterm infants.
Fifty preterm babies were randomly assigned to a group given oral bucolome (30 mg/kg per day for 5 days) and a control group… 
1977
1977
Bile-salt-dependent and independent choleresis induced by bucolome in the rat.
Choleresis induced by bucolome (BC) (1-cyclohexyl-5-n-butyl-2,4,6-trioxoperhydropyrimidine) was studied in male Wistar rats. [14C… 
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