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bucolome
Known as:
1-cyclohexyl-5-butylbarbituric acid
, 2,4,6(1H,3H,5H)-Pyrimidnetrione, 5-butyl-1-cyclohexyl-
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Barbital
Barbiturates
Narrower (1)
Paramidine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Effects of combination therapy with warfarin and bucolome for anticoagulation in patients with atrial fibrillation.
H. Obata
,
H. Watanabe
,
+4 authors
Y. Aizawa
Circulation journal : official journal of the…
2011
Corpus ID: 8819835
BACKGROUND Bucolome, a nonsteroidal antiinflammatory drug, enhances the effects of warfarin. In the present study, the effects of…
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2008
2008
The effect of bucolome, a CYP2C9 inhibitor, on the pharmacokinetics of losartan.
M. Kobayashi
,
M. Takagi
,
K. Fukumoto
,
R. Kato
,
K. Tanaka
,
K. Ueno
Drug metabolism and pharmacokinetics
2008
Corpus ID: 26104963
Losartan, a selective angiotensin receptor antagonist, is mainly metabolized by CYP2C9 to an active carboxylic acid, E3174, which…
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2005
2005
BUCOLOME, A POTENT BINDING INHIBITOR FOR FUROSEMIDE, ALTERS THE PHARMACOKINETICS AND DIURETIC EFFECT OF FUROSEMIDE: POTENTIAL FOR USE OF BUCOLOME TO RESTORE DIURETIC RESPONSE IN NEPHROTIC SYNDROME
N. Takamura
,
T. Maruyama
,
+6 authors
M. Otagiri
Drug Metabolism and Disposition
2005
Corpus ID: 1184330
To determine whether bucolome (5-n-butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine), a nonsteroidal anti-inflammatory agent…
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2005
2005
Usefulness of coadministration of bucolome in warfarin therapy: pharmacokinetic and pharmacodynamic analysis using outpatient prescriptions.
M. Osawa
,
Nobuko Hada
,
+7 authors
K. Sugibayashi
International journal of pharmaceutics
2005
Corpus ID: 43849749
Bucolome, a nonsteroidal anti-inflammatory drug, has often been coadministered to patients who take warfarin as an anticoagulant…
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2001
2001
The Stereoselective Effects of Bucolome on the Pharmacokinetics and Pharmacodynamics of Racemic Warfarin
K. Matsumoto
,
Shigenobu Ishida
,
+6 authors
M. Shibakawa
Journal of clinical pharmacology
2001
Corpus ID: 33125554
The objective of this study was to investigate the stereoselective influence of bucolome on the pharmacokinetics and…
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1999
1999
Pharmacokinetic interaction between warfarin and a uricosuric agent, bucolome: application of In vitro approaches to predicting In vivo reduction of (S)-warfarin clearance.
H. Takahashi
,
T. Kashima
,
+7 authors
A. H. Echizen
Drug metabolism and disposition: the biological…
1999
Corpus ID: 2621388
A uricosuric agent, bucolome, has been shown to intensify the anticoagulant effect of warfarin. The aims of the present study…
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1985
1985
Bucolome N-glucuronide: purification and identification of a major metabolite of bucolome in rat bile.
K. Mohri
,
T. Uesugi
,
K. Kamisaka
Xenobiotica; the fate of foreign compounds in…
1985
Corpus ID: 33563956
A biliary metabolite of bucolome in rat was isolated and purified by column chromatography. The metabolite has been identified as…
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1978
1978
Danger of bucolome in infants with hyperbilirubinaemia. Experimental evidence.
R. Semba
,
H. Sato
,
H. Yamamura
Archives of disease in childhood
1978
Corpus ID: 11461934
Effects of bucolome on congenitally jaundiced Gunn rats were examined. Plasma total bilirubin level fell immediately after a…
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1977
1977
Bucolome in prevention of hyperbilirubinaemia in preterm infants.
G. Segni
,
Giancarlo Polidori
,
C. Romagnoli
Archives of disease in childhood
1977
Corpus ID: 1211588
Fifty preterm babies were randomly assigned to a group given oral bucolome (30 mg/kg per day for 5 days) and a control group…
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1977
1977
Bile-salt-dependent and independent choleresis induced by bucolome in the rat.
K. Kitani
,
Y. Morita
,
R. Miura
,
S. Kanai
Canadian journal of physiology and pharmacology
1977
Corpus ID: 23294591
Choleresis induced by bucolome (BC) (1-cyclohexyl-5-n-butyl-2,4,6-trioxoperhydropyrimidine) was studied in male Wistar rats. [14C…
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