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bromotetrandrine

Known as: W198 
National Institutes of Health

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Broader (1)

Benzylisoquinolines

Papers overview

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2010
2010
Pharmacokinetics and safety of bromotetrandrine (BrTet, W198) after single‐dose intravenous administration in healthy Chinese volunteers
Objective:  To investigate the safety and pharmacokinetics of bromotetrandrine (BrTet, W198), a novel inhibitor of P‐glycoprotein… 
2009
2009
Reversal of P-gp-mediated multidrug resistance by Bromotetrandrine in vivo is associated with enhanced accumulation of chemotherapeutical drug in tumor tissue.
BACKGROUND Our previous studies have shown that tetrandrine (Tet) reverses the effect of P-glycoprotein (P-gp)-mediated multidrug… 
2009
2009
Liquid chromatographic/mass spectrometry assay of bromotetrandrine in rat plasma and its application to pharmacokinetic study.
A rapid and sensitive liquid chromatography-tandem mass spectrometric method (LC-MS/MS) for the determination of bromotetrandrine… 
2007
2007
Reversal of P-Glycoprotein-Dependent Resistance to Adriamycin by 5-bromotetrandrine in K562/A02 Cell Line.
Objective: The present study aimed to evaluate the MDR reversal activity of bromotetrandrine (BrTet), a bromized derivative of… 
2005
2005
[Tissue distribution and excretion of bromotetrandrine in rats].
AIM To study the tissue distribution and excretion of bromotetrandrine (W198) in rats. METHODS The concentrations of W198 in… 
2004
2004
Studies on pharmacokinetics of bromotetrandrine in animals (II). Effect of coadministration of bromotetrandrine with adriamycin on the pharmacokinetics
Aim To study the pharmacokinetics after combination of bromotetrandrine (W198) with adriamycin in rats. Methods Two HPLC methods… 
2004
2004
[Pharmacokinetics of bromotetrandrin (W198) in rats and beagle dogs].
AIM To study the pharmacokinetics of bromotetrandrine (W198) in rats and beagle dogs. METHODS The concentrations of W198 in… 
2004
2004
Studies on toxicokinetics of single or combination administration of bromotetrandrine and adriamycin in beagle dogs
AIM: To study the toxicokinetics after single or combination administration of bromotetrandrine (W198) and adriamycin in beagle… 
2003
2003
A statistical procedure [CHAIN] to study protein kinase structural mechanisms
Protein kinases phosphorylate a variety of protein substrates in the eukaryotic cell and exhibit different modes of activation… 
2000
2000
W198 気管支喘息(BA)に合併した早期反復性多発性軟骨炎(PR)一例治療の検討
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