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The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells.
TLDR
It is found that upregulation of Bmi-1 induced epithelial-mesenchymal transition (EMT) and enhanced the motility and invasiveness of human nasopharyngeal epithelial cells, whereas silencing endogenous Bmi -1 expression reversed EMT and reduced motility.
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.
TLDR
It is concluded that erlotinib reverses ABCB 1- and ABCG2-mediated MDR in cancer cells through direct inhibition of the drug efflux function of ABCB1 andABCG2.
Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells.
TLDR
This study provides the first cellular proto-oncogene immortalized nasopharyngeal epithelial cell line, which may serve as a cell model system for studying the mechanisms involved in the tumorigenesis of nasopharygeal carcinoma.
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.
TLDR
Investigation of the ability of lapatinib to reverse tumor multidrug resistance (MDR) due to overexpression of ABC subfamily B member 1 (ABCB1) and ABCsubfamily G member 2 (ABCG2) transporters found it reverses ABCB1- and ABCG2-mediated MDR by directly inhibiting their transport function.
Mechanisms of resistance to BCR-ABL TKIs and the therapeutic strategies: A review.
  • Ke Yang, L. Fu
  • Biology, Chemistry
    Critical reviews in oncology/hematology
  • 1 March 2015
Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters.
TLDR
It is shown that apatinib reverses ABCB1- and ABCG2-mediated MDR by inhibiting their transport function, but not by blocking the AKT or ERK1/2 pathway or downregulating ABCB 1 or ABCG 2 expression.
Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.
TLDR
It is reported that sildenafil has differential effects on cell surface ABC transporters such as ABCB1, ABCC1, and ABCG2 that modulate intracompartmental and intracellular concentrations of chemotherapeutic drugs.
Crizotinib (PF‐02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P‐glycoprotein
TLDR
The possible reversal of multidrug resistance (MDR) by crizotinib in vitro and in vivo is assessed.
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