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brobactam

Known as: 6 beta-bromopenicillanic acid, 6-bromopenicillanic acid 
A synthetic inhibitor of beta-lactamases produced by both gram-positive and gram-negative bacteria. Brobactam potentiates the antibacterial activity… 
National Institutes of Health

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3 relations

Broader (2)

Penicillanic Acidbeta-Lactamase Inhibitors
analogs & derivatives

Papers overview

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2002
2002
Synthesis and biological evaluation of 6-bromo-6-substituted penicillanic acid derivatives as beta-lactamase inhibitors.
The synthesis of a selected set of 6-bromopenicillanic acid derivatives with an additional C6 substituent is reported. All these… 
1987
1987
Structure-activity relationships of 6-(heterocyclyl)-methylene penam sulfones; a new class of beta-lactamase inhibitors.
6-(Heterocyclyl)methylene penam sulfones (1) are effective beta-lactamase inhibitors and potent ampicillin and cefazolin… 
1987
1987
In vitro activity of ampicillin alone and in combination with different concentrations of 6 beta-bromopenicillanic acid, clavulanic acid and mecillinam.
The antibacterial activity of ampicillin against Enterobacteriaceae strongly increased when combined with 6 beta… 
1986
1986
In-vitro activity of the combinations of ampicillin with mecillinam or with beta-lactamase inhibitors against strains resistant to ampicillin.
The in-vitro activity of ampicillin, of mecillinam and of combinations of ampicillin with mecillinam, clavulanic acid or 6 beta… 
1985
1985
Synthesis of deuterium- and tritium-labeled 6 beta-bromopenicillanic acid.
The synthesis of 6 beta-bromopenicillanic acid labeled with deuterium and tritium in the beta-methyl group is described. The S… 
1983
1983
Characterization of the membrane beta-lactamase in Bacillus cereus 569/H/9.
The membrane-bound beta-lactamase from Bacillus cereus, strain 569/H/9, has been purified to apparent homogeneity. Nonionic… 
1980
1980
Kinetics of inactivation of beta-lactamase I by 6 beta-bromopenicillanic acid.
The kinetics of the inactivation of beta-lactamase I from Bacillus cereus 569 by preparations of 6 alpha-bromopenicillanic acid… 
1980
1980
Inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopenicillanic acid: kinetics.
The kinetics of the inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopenicillanic acid are described. Loss of beta… 
1980
1980
Inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopencillanic acid: mechanism.
The mechanism of the inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopenicillanic acid, a probable suicide… 
1980
1980
On the chemistry of beta-lactamase inhibition by 6 beta-bromopenicillanic acid.
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