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brentuximab vedotin

Known as: CAC10-1006, cAC10-vcMMAE 
An antibody-drug conjugate (ADC) directed against the tumor necrosis factor (TNF) receptor CD30 with potential antineoplastic activity. Brentuximab… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
PURPOSE Locally advanced or metastatic urothelial carcinoma is an incurable disease with limited treatment options, especially… Expand
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Review
2019
Review
2019
A multitude of new agents for the treatment of hematologic malignancies has been introduced over the past decade. Hematologists… Expand
Review
2019
Review
2019
Targeted delivery of therapeutic molecules into cancer cells is considered as a promising strategy to tackle cancer. Antibody… Expand
Review
2019
Review
2019
BACKGROUND Based on the encouraging activity and manageable safety profile observed in a phase 1 study, the ECHELON-2 trial was… Expand
Review
2019
Review
2019
ABSTRACT For the past 10 years, the annual ‘Antibodies to watch’ articles have provided updates on key events in the late-stage… Expand
Highly Cited
2016
Highly Cited
2016
Purpose Classical Hodgkin lymphoma (HL) frequently exhibits genetic alterations leading to overexpression of the programmed death… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Preclinical studies suggest that Reed-Sternberg cells exploit the programmed death 1 (PD-1) pathway to evade immune… Expand
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Highly Cited
2012
Highly Cited
2012
Progress has been made recently in developing antibody-drug conjugates (ADCs) that can selectively deliver cancer drugs to tumor… Expand
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Highly Cited
2012
Highly Cited
2012
In August 2011 brentuximab vedotin (Adcetris; Seattle Genetics), a CD30-specific antibody–drug conjugate, was approved by the US… Expand
Highly Cited
2010
Highly Cited
2010
BACKGROUND Hodgkin's lymphoma and anaplastic large-cell lymphoma are the two most common tumors expressing CD30. Previous… Expand
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