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bouchardatine

 
National Institutes of Health

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Indole Alkaloids

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2019
2019
Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1α-UCP2 axis.
Cancer metabolism is an attractive target of the therapeutic strategy for cancer. The present study identified bouchardatine (Bou… Expand
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2019
2019
Bouchardatine analogue alleviates non‐alcoholic hepatic fatty liver disease/non‐alcoholic steatohepatitis in high‐fat fed mice by inhibiting ATP synthase activity
Background and Purpose Non‐alcoholic hepatic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in the… Expand
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2019
2019
Bouchardatine analogue alleviates NAFLD/NASH in high fat fed mice via blunting ATP synthase activity.
BACKGROUND AND PURPOSE Non-alcoholic hepatic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome (MetS) in liver… Expand
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2018
2018
Design, synthesis and biological evaluation of novel bouchardatine analogs as potential inhibitors of adipogenesis/lipogenesis in 3T3-L1 adipocytes.
Inhibition of the differentiation of adipocytes and reduced lipid synthesis are efficacious approaches for treating obesity… Expand
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2017
2017
Natural alkaloid bouchardatine ameliorates metabolic disorders in high‐fat diet‐fed mice by stimulating the sirtuin 1/liver kinase B‐1/AMPK axis
BACKGROUND AND PURPOSE Promoting energy metabolism is known to provide therapeutic effects for obesity and associated metabolic… Expand
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2016
2016
Synthesis of bouchardatine and its derivatives with lipid-lowering effect
 
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2015
2015
Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment.
Our recent study has shown that the natural product bouchardatine (1) can reduce the triglyceride (TG) content in 3T3-L1… Expand
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2015
2015
Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes.
Bouchardatine (1), a naturally occurring β-indoloquinazoline alkaloid, was synthesized. For the first time, the lipid-lowering… Expand
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2011
2011
[Synthesis, physicochemical and pharmacological properties of pentacyclic alkaloid-analogues].
Quinazolinocarboline rutaecarpine and evodiamine (Evodia rutaecarpa) are main alkaloid components of traditional Chinese folk… Expand
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2003
2003
Alkaloids and limonoids from Bouchardatia neurococca: systematic significance.
Five alkaloids, four beta-indoloquinazoline and one furoquinoline, and four terpenoids, three limonoids and one modified… Expand
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