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boranophosphate

 
National Institutes of Health

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Broader (2)

Boranesinorganic phosphate

Papers overview

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2014
2014
Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes
Modified mRNA cap analogs aid in the study of mRNA-related processes and may enable creation of novel therapeutic interventions… Expand
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2012
2012
Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues.
Dinucleoside polyphosphates, Np(n)N', exert their physiological effects via P2 receptors (P2Rs). Np(n)N' are attractive drug… Expand
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2010
2010
1,2-Trans-selective synthesis of glycosyl boranophosphates and their utility as building blocks for the synthesis of phosphodiester-linked disaccharides.
A highly 1,2-trans-selective synthesis of glycosyl boranophosphate derivatives by glycosylation of dimethyl boranophosphate with… Expand
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2008
2008
Boranophosphate siRNA-aptamer chimeras for tumor-specific downregulation of cancer receptors and modulators.
There is a need for novel, effective, and cell- and gene-specific therapeutics for cancer. Modified oligonucleotides can be used… Expand
Highly Cited
2006
Highly Cited
2006
High potency silencing by single-stranded boranophosphate siRNA
In RNA interference (RNAi), double-stranded short interfering RNA (ds-siRNA) inhibits expression from complementary mRNAs… Expand
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2006
2006
Solid-phase synthesis of oligodeoxyribonucleoside boranophosphates by the boranophosphotriester method.
Oligodeoxyribonucleoside boranophosphates (BH3-ODNs), containing four kinds of nucleobases, were synthesized by the solid-phase… Expand
Highly Cited
2004
Highly Cited
2004
RNA interference using boranophosphate siRNAs: structure-activity relationships.
In RNA interference (RNAi), short double-stranded RNA (known as siRNA) inhibits expression from homologous genes. Clinical or pre… Expand
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2003
2003
Reading, Writing, and Modulating Genetic Information with Boranophosphate Mimics of Nucleotides, DNA, and RNA
Abstract: The P‐boranophosphates are efficient and near perfect mimics of natural nucleic acids in permitting reading and writing… Expand
2000
2000
Boranophosphate backbone: a mimic of phosphodiesters, phosphorothioates, and methyl phosphonates.
Nucleoside boranophosphates are distinctive in that one of the non-bridging oxygens in the phosphate diester 1 is replaced by a… Expand
1999
1999
Boranophosphates support the RNase H cleavage of polyribonucleotides.
  • V. Rait, B. Shaw
  • Antisense & nucleic acid drug development
  • 1999
    • Corpus ID: 23527265
Modification of the phosphodiester linkages in DNA by replacing one of the nonbridging oxygens with borane, BH3, produces an… Expand
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