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boranophosphate

 
National Institutes of Health

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Broader (2)

Boranesinorganic phosphate

Papers overview

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2018
2018
Rational Design and Facile Synthesis of Boranophosphate Ionic Liquids as Hypergolic Rocket Fuels.
The design and synthesis of new hypergolic ionic liquids (HILs) as replacements for toxic hydrazine derivatives have been the… Expand
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2014
2014
Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes
Modified mRNA cap analogs aid in the study of mRNA-related processes and may enable creation of novel therapeutic interventions… Expand
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2013
2013
Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug design.
Improved treatments for chronic HCV infections remain a challenge, and new chemical strategies are needed to expand the current… Expand
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2012
2012
Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues.
Dinucleoside polyphosphates, Np(n)N', exert their physiological effects via P2 receptors (P2Rs). Np(n)N' are attractive drug… Expand
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2008
2008
Boranophosphate siRNA-aptamer chimeras for tumor-specific downregulation of cancer receptors and modulators.
There is a need for novel, effective, and cell- and gene-specific therapeutics for cancer. Modified oligonucleotides can be used… Expand
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2006
2006
High potency silencing by single-stranded boranophosphate siRNA
In RNA interference (RNAi), double-stranded short interfering RNA (ds-siRNA) inhibits expression from complementary mRNAs… Expand
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Highly Cited
2004
Highly Cited
2004
RNA interference using boranophosphate siRNAs: structure-activity relationships.
In RNA interference (RNAi), short double-stranded RNA (known as siRNA) inhibits expression from homologous genes. Clinical or pre… Expand
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2003
2003
Reading, writing, and modulating genetic information with boranophosphate mimics of nucleotides, DNA, and RNA.
The P-boranophosphates are efficient and near perfect mimics of natural nucleic acids in permitting reading and writing of… Expand
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2000
2000
Boranophosphate backbone: a mimic of phosphodiesters, phosphorothioates, and methyl phosphonates.
Nucleoside boranophosphates are distinctive in that one of the non-bridging oxygens in the phosphate diester 1 is replaced by a… Expand
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1999
1999
Boranophosphates support the RNase H cleavage of polyribonucleotides.
Modification of the phosphodiester linkages in DNA by replacing one of the nonbridging oxygens with borane, BH3, produces an… Expand
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