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A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy.
Previously it has not been possible to determine the rate of deamination of cytosine in DNA at 37 degrees C because this reaction occurs so slowly. We describe here a sensitive genetic assay toExpand
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Conjugates of Antisense Oligonucleotides with the Tat and Antennapedia Cell-Penetrating Peptides: Effects on Cellular Uptake, Binding to Target Sequences, and Biologic Actions
AbstractPurpose. The attainment of effective intracellular delivery remains an important issue for pharmacologic applications of antisense oligonucleotides. Here, we describe the synthesis, bindingExpand
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Cytosine deamination in mismatched base pairs.
The rate of deamination of cytosine in mismatched base pairs has been determined. Incubation of M13mp2 nicked heteroduplex DNA molecules containing T.C or C.C mispairs in the lacZExpand
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Boron-containing aptamers to ATP.
Boron neutron capture therapy (BNCT), an experimental treatment for certain cancers, destroys only cells near the boron; however, there is a need to develop highly specific delivery agents. AsExpand
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Evaluating the Specificity of Antisense Oligonucleotide Conjugates
Antisense oligonucleotides are potentially powerful tools for selective control of cellular and viral gene expression. Crucial to successful application of this approach is the specificity of theExpand
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High potency silencing by single-stranded boranophosphate siRNA
In RNA interference (RNAi), double-stranded short interfering RNA (ds-siRNA) inhibits expression from complementary mRNAs. Recently, it was demonstrated that short, single-stranded antisense RNAExpand
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Nucleoside and oligonucleoside boranophosphates: chemistry and properties.
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INCORPORATION OF RIBONUCLEOSIDE 5′-(α-P-BORANO)TRIPHOSPHATES INTO A 20-MER RNA BY T7 RNA POLYMERASE
  • J. Wan, B. Shaw
  • Chemistry, Medicine
  • Nucleosides, nucleotides & nucleic acids
  • 1 April 2005
The enzymatic synthesis of short boranophosphate RNA was studied by comparing the yield and pattern of abortive products of in vitro transcription at steady-state conditions with that of normal RNA.Expand
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TREC video retrieval evaluation TRECVID 2010 (slides)
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Analysis of subunit organization in chicken erythrocyte chromatin.
Micrococcal nuclease digestion of intact chicken erythrocyte nuclei is shown to result in the formation of core nucleoprotein particles containing about 140 base pairs of DNA. These core particles,Expand
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