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Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly… Expand BACKGROUND
There is currently no standard of care for treatment of negative symptoms of schizophrenia, although some previous… Expand BACKGROUND
Many patients with schizophrenia require high doses of medication for their ongoing psychotic symptoms. Glutamate… Expand Objective: We aimed to review research on smoking and mental illness and provide evidence-based guidelines for psychiatrists to… Expand IMPORTANCE
In schizophrenia, the severity of negative symptoms is a key predictor of long-term disability. Deficient signaling… Expand Bitopertin is a glycine reuptake inhibitor postulated to improve N-methyl-d-aspartate receptor hypofunction by increasing… Expand In this issue, Umbricht and colleagues1 reported improvement of negative symptoms of schizophrenia associated with 2 of 3 doses… Expand Current treatments for schizophrenia, although effective for positive symptoms, have not proven as effective for negative… Expand Severe psychiatric disorders such as schizophrenia are related to cognitive and negative symptoms, which often are resistant to… Expand Evidence-based medicine (EBM) is a broad concept, but the key elements include the incorporation of clinical judgment (which… Expand