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bitopertin

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Bitopertin Not Effective for Negative Symptoms of Schizophrenia
Deficits in the NMDA receptor (NMDAR) signaling have been associated with negative symptoms of schizophrenia, and preliminary… 
2017
2017
Evaluation of the Subjective Similarity of the GlyT1 Inhibitor Bitopertin to Five Drugs of Abuse Using Drug Discrimination Testing in the Rat
Review
2017
Review
2017
Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities
This review gives a perspective on the current “state of the art” in metabolic drug-drug interaction (DDI) prediction. We… 
2016
2016
Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers
Hypofunction of NMDA receptors has been implicated in neuropsychiatric disorders including schizophrenia. NMDA receptor… 
2016
2016
Bitopertin in schizophrenia: glass half full?
2016
2016
Preclinical Reproductive and Developmental Toxicity Profile of a Glycine Transporter Type 1 (Glyt1) Inhibitor.
Bitopertin is a glycine type 1 (GlyT1) inhibitor intended for the treatment of psychiatric disorders. The principle adverse… 
2015
2015
Translating the Glutamatergic Hypothesis of Schizophrenia Through Homeostatic Regulation of Brain Glycine
No effective treatment exists for the negative symptoms and cognitive impairments of schizophrenia. The loss of normal affective… 
2014
2014
Effects of Clozapine, Aripiprazole and Bitopertin in Rats Social Withdrawal Assessed in an Automatic Social Interaction Test
In healthy volunteers, the NMDA receptor antagonists phencyclidine (PCP) and ketamine induce psychotomimetic effects mirroring… 
2014
2014
Bitopertin als neue Medikations-Alternative?
2012
2012
Optimising therapy for schizophrenia and depression: old and new solutions
Schizophrenia and depression were in the spotlight at the Latest Advances in Psychiatry Symposium XI held in London in March 2012… 
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