Skip to search formSkip to main contentSkip to account menu

bitopertin

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Phase 2 Clinical Trial Results for Bitopertin, an Oral Glycine Transporter 1 Inhibitor, in Patients with Non-Transfusion Dependent Beta-Thalassemia
Beta-thalassemia is a hereditary blood disorder characterized by reduced or absent synthesis of the beta-globin chain, one of… 
2017
2017
Bitopertin Not Effective for Negative Symptoms of Schizophrenia
Deficits in the NMDA receptor (NMDAR) signaling have been associated with negative symptoms of schizophrenia, and preliminary… 
Review
2016
Review
2016
Cardiovascular safety assessments in the cynomolgus monkey: Unmasking potential background arrhythmias in general toxicity studies.
2016
2016
Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers
Hypofunction of NMDA receptors has been implicated in neuropsychiatric disorders including schizophrenia. NMDA receptor… 
2016
2016
Bitopertin in schizophrenia: glass half full?
2016
2016
Preclinical Reproductive and Developmental Toxicity Profile of a Glycine Transporter Type 1 (Glyt1) Inhibitor.
Bitopertin is a glycine type 1 (GlyT1) inhibitor intended for the treatment of psychiatric disorders. The principle adverse… 
Review
2014
Review
2014
Glutamatergic drugs for schizophrenia treatment.
It is accepted that both positive and negative symptoms of schizophrenia may be due to hypofunction of glutamatergic pathways… 
2014
2014
Effects of Clozapine, Aripiprazole and Bitopertin in Rats Social Withdrawal Assessed in an Automatic Social Interaction Test
In healthy volunteers, the NMDA receptor antagonists phencyclidine (PCP) and ketamine induce psychotomimetic effects mirroring… 
2014
2014
Bitopertin als neue Medikations-Alternative?
2012
2012
Optimising therapy for schizophrenia and depression: old and new solutions
Schizophrenia and depression were in the spotlight at the Latest Advances in Psychiatry Symposium XI held in London in March 2012… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)