• Publications
  • Influence
Recent advances in the phencyclidine model of schizophrenia.
  • D. Javitt, S. Zukin
  • Psychology, Medicine
  • The American journal of psychiatry
  • 1 October 1991
OBJECTIVE Phencyclidine (PCP, "angel dust") induces a psychotomimetic state that closely resembles schizophrenia. As opposed to amphetamine-induced psychosis, PCP-induced psychosis incorporates bothExpand
Multisensory auditory-visual interactions during early sensory processing in humans: a high-density electrical mapping study.
Integration of information from multiple senses is fundamental to perception and cognition, but when and where this is accomplished in the brain is not well understood. This study examined the timingExpand
Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
Many risk genes interact synergistically to produce schizophrenia and many neurotransmitter interactions have been implicated. We have developed a circuit-based framework for understanding gene andExpand
The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry
The National Institute of Mental Health strategic plan for advancing psychiatric neuroscience calls for an acceleration of discovery and the delineation of developmental trajectories for risk andExpand
Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia.
BACKGROUND In patients with schizophrenia, deficient generation of mismatch negativity (MMN)-an event-related potential (ERP) indexing auditory sensory ("echoic") memory-and a selective increase ofExpand
Grabbing your ear: rapid auditory-somatosensory multisensory interactions in low-level sensory cortices are not constrained by stimulus alignment.
Multisensory interactions are observed in species from single-cell organisms to humans. Important early work was primarily carried out in the cat superior colliculus and a set of critical parametersExpand
The neural circuitry of pre-attentive auditory change-detection: an fMRI study of pitch and duration mismatch negativity generators.
Electrophysiological studies have revealed a pre-attentive change-detection system in the auditory modality. This system emits a signal termed the mismatch negativity (MMN) when any detectable changeExpand
The Spectrotemporal Filter Mechanism of Auditory Selective Attention
Although we have convincing evidence that attention to auditory stimuli modulates neuronal responses at or before the level of primary auditory cortex (A1), the underlying physiological mechanismsExpand
From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment
Glutamate is the primary excitatory neurotransmitter in mammalian brain. Disturbances in glutamate-mediated neurotransmission have been increasingly documented in a range of neuropsychiatricExpand
Do you see what I am saying? Exploring visual enhancement of speech comprehension in noisy environments.
We show that the multisensory speech system is maximally tuned for SNRs between extremes, where the system relies on either the visual (speech-reading) or the auditory modality alone, forming a window of maximal integration at intermediate SNR levels. Expand