beta-amyloid formation

Known as: beta-amyloid polypeptide formation from APP, beta-amyloid polypeptide formation from amyloid precursor protein 
The generation of beta-amyloid by cleavage of the amyloid precursor protein (APP). [GOC:mah]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
02419912017

Papers overview

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2009
2009
S-Adenosylhomocysteine (SAH) has been implicated as a risk factor for neurodegenerative diseases such as Alzheimer's disease. As… (More)
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2008
Highly Cited
2008
beta-Secretase plays a critical role in beta-amyloid formation and thus provides a therapeutic target for Alzheimer's disease… (More)
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2006
2006
Presenilin (PS1/PS2) is a major component of gamma-secretase, the activity that mediates proteolysis of beta-amyloid precursor… (More)
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2000
2000
A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the… (More)
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2000
2000
Epidemiological studies indicated that cigarette smoking protects against the development of several neurodegenerative disorders… (More)
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1999
1999
We report that certain plasma proteins, at physiological concentrations, are potent inhibitors of amyloid beta-peptide (Abeta… (More)
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1997
1997
Several reports have suggested that the frequency of Alzheimer's disease (AD) neuropathology is significantly reduced in elderly… (More)
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1996
Highly Cited
1996
The beta-amyloid peptide, the hallmark of Alzheimer disease, forms fibrillar toxic aggregates in brain tissue that can be… (More)
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1993
1993
Alzheimer beta-amyloid protein precursor (beta APP) is expressed endogenously and abundantly by human neuroglioma (H4) cells. Its… (More)
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1991
1991
Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide… (More)
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