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beta-amyloid formation

Known as: beta-amyloid polypeptide formation from APP, beta-amyloid polypeptide formation from amyloid precursor protein 
The generation of beta-amyloid by cleavage of the amyloid precursor protein (APP). [GOC:mah]
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
β-Secretase plays a critical role in β-amyloid formation and thus provides a therapeutic target for Alzheimer's disease… Expand
Highly Cited
2007
Highly Cited
2007
The brain pathology of Alzheimer's disease is characterized by abnormally aggregated Abeta in extracellular beta-amyloid plaques… Expand
Highly Cited
2006
Highly Cited
2006
Presenilin (PS1/PS2) is a major component of gamma-secretase, the activity that mediates proteolysis of beta-amyloid precursor… Expand
Highly Cited
2006
Highly Cited
2006
Interest in self-association of peptides and proteins is motivated by an interest in the mechanism of physiologically higher… Expand
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Review
2000
Review
2000
Abstract: A pathological glia activation, stimulated by inflammatory proteins, β‐amyloid, or brain ischemia, is discussed as a… Expand
Highly Cited
1999
Highly Cited
1999
We report that certain plasma proteins, at physiological concentrations, are potent inhibitors of amyloid beta-peptide (Abeta… Expand
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Highly Cited
1998
Highly Cited
1998
Microglial activation is central to the inflammatory response in Alzheimer's Disease (AD). A recently described mouse line, Tg… Expand
Highly Cited
1996
Highly Cited
1996
The beta-amyloid peptide, the hallmark of Alzheimer disease, forms fibrillar toxic aggregates in brain tissue that can be… Expand
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Highly Cited
1993
Highly Cited
1993
Alzheimer beta-amyloid protein precursor (beta APP) is expressed endogenously and abundantly by human neuroglioma (H4) cells. Its… Expand
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Highly Cited
1991
Highly Cited
1991
Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide… Expand