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beta-amyloid formation

Known as: beta-amyloid polypeptide formation from APP, beta-amyloid polypeptide formation from amyloid precursor protein 
The generation of beta-amyloid by cleavage of the amyloid precursor protein (APP). [GOC:mah]
National Institutes of Health

Papers overview

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2009
2009
S-Adenosylhomocysteine (SAH) has been implicated as a risk factor for neurodegenerative diseases such as Alzheimer's disease. As… Expand
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Highly Cited
2008
Highly Cited
2008
β-Secretase plays a critical role in β-amyloid formation and thus provides a therapeutic target for Alzheimer's disease… Expand
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Highly Cited
2007
Highly Cited
2007
The brain pathology of Alzheimer's disease is characterized by abnormally aggregated Abeta in extracellular beta-amyloid plaques… Expand
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Highly Cited
2006
Highly Cited
2006
Interest in self-association of peptides and proteins is motivated by an interest in the mechanism of physiologically higher… Expand
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Highly Cited
2006
Highly Cited
2006
Presenilin (PS1/PS2) is a major component of gamma-secretase, the activity that mediates proteolysis of beta-amyloid precursor… Expand
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Review
2000
Review
2000
A pathological glia activation, stimulated by inflammatory proteins, beta-amyloid, or brain ischemia, is discussed as a common… Expand
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Highly Cited
1999
Highly Cited
1999
We report that certain plasma proteins, at physiological concentrations, are potent inhibitors of amyloid beta-peptide (Abeta… Expand
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Highly Cited
1998
Highly Cited
1998
Microglial activation is central to the inflammatory response in Alzheimer's Disease (AD). A recently described mouse line, Tg… Expand
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Highly Cited
1993
Highly Cited
1993
Alzheimer beta-amyloid protein precursor (beta APP) is expressed endogenously and abundantly by human neuroglioma (H4) cells. Its… Expand
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Highly Cited
1991
Highly Cited
1991
Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide… Expand
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