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β-Secretase plays a critical role in β-amyloid formation and thus provides a therapeutic target for Alzheimer's disease… Expand The brain pathology of Alzheimer's disease is characterized by abnormally aggregated Abeta in extracellular beta-amyloid plaques… Expand Presenilin (PS1/PS2) is a major component of gamma-secretase, the activity that mediates proteolysis of beta-amyloid precursor… Expand Interest in self-association of peptides and proteins is motivated by an interest in the mechanism of physiologically higher… Expand Abstract: A pathological glia activation, stimulated by inflammatory proteins, β‐amyloid, or brain ischemia, is discussed as a… Expand We report that certain plasma proteins, at physiological concentrations, are potent inhibitors of amyloid beta-peptide (Abeta… Expand Microglial activation is central to the inflammatory response in Alzheimer's Disease (AD). A recently described mouse line, Tg… Expand The beta-amyloid peptide, the hallmark of Alzheimer disease, forms fibrillar toxic aggregates in brain tissue that can be… Expand Alzheimer beta-amyloid protein precursor (beta APP) is expressed endogenously and abundantly by human neuroglioma (H4) cells. Its… Expand Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide… Expand