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berberrubine

National Institutes of Health

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Broader (1)

Berberine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice
Ulcerative colitis (UC) is a chronic relapsing disease without satisfactory treatments, in which intestinal inflammation and… Expand
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Highly Cited
2014
Highly Cited
2014
Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects.
Berberine (1) is an alkaloid used widely in the treatment of several diseases. However, its physicochemical properties… Expand
Highly Cited
2013
Highly Cited
2013
Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats
Berberine (BBR) has been confirmed to have multiple bioactivities in clinic, such as cholesterol-lowering, anti-diabetes… Expand
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Review
2011
Review
2011
Therapeutic potential of nucleic acid‐binding isoquinoline alkaloids: Binding aspects and implications for drug design
Isoquinoline alkaloids represent a group of natural products with remarkable importance in the contemporary biomedical research… Expand
2010
2010
Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine.
In order to enhance oral bioavailability of berberine (BBR) for its cholesterol-lowering efficacy in vivo, a series of ester or… Expand
Highly Cited
2006
Highly Cited
2006
Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents.
By introducing various aromatic groups in 13-C of berberine and berberrubine, a series of 13-(substituted benzyl) berberine and… Expand
Highly Cited
2006
Highly Cited
2006
Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry
Berberine (Ber) and its main metabolites were identified and quantified using liquid chromatography/electrospray ionization/ion… Expand
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2002
2002
Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine.
Berberrubine, a protoberberine alkaloid that exhibits antitumor activity in animal models, has been identified as a specific… Expand
Highly Cited
1998
Highly Cited
1998
Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine.
Topoisomerase II is the cytotoxic target for a number of clinically relevant antitumor drugs. Berberrubine, a protoberberine… Expand
1976
1976
Antitumor activity of berberrubine derivatives.
The antitumor activity of berberine, berberrubine, and their derivatives against sarcoma-180 ascites was determined by the total… Expand
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