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berberrubine

National Institutes of Health

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Berberine
analogs & derivatives

Papers overview

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Highly Cited
2018
Highly Cited
2018
Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice
Ulcerative colitis (UC) is a chronic relapsing disease without satisfactory treatments, in which intestinal inflammation and… 
2017
2017
In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine
Berberrubine (BRB) is the primary metabolite of berberine (BBR) that has shown a stronger glucose-lowering effect than BBR in… 
Highly Cited
2013
Highly Cited
2013
Excretion of berberine and its metabolites in oral administration in rats.
Berberine (BBR) has been confirmed to show extensive bioactivities for the treatments of diabetes and hypercholesterolemia in… 
Highly Cited
2006
Highly Cited
2006
Synthesis, DNA-binding affinities, and binding mode of berberine dimers.
Highly Cited
2005
Highly Cited
2005
Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities.
Highly Cited
2005
Highly Cited
2005
Spectrometric studies of cytotoxic protoberberine alkaloids binding to double-stranded DNA.
2003
2003
Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents.
2002
2002
Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine.
Berberrubine, a protoberberine alkaloid that exhibits antitumor activity in animal models, has been identified as a specific… 
Highly Cited
1998
Highly Cited
1998
Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine.
Topoisomerase II is the cytotoxic target for a number of clinically relevant antitumor drugs. Berberrubine, a protoberberine… 
1976
1976
Antitumor activity of berberrubine derivatives.
The antitumor activity of berberine, berberrubine, and their derivatives against sarcoma-180 ascites was determined by the total… 
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