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beclobrate

Known as: 2-(4-((4-chlorophenyl)methyl)phenoxy)-2-methylbutanoic acid ethyl ester, Butanoic acid, 2-(4-((4-chlorophenyl)methyl)phenoxy)-2-methyl-, ethyl ester, (+-)- 
A structural analog of clofibrate, converted to its free acid form after oral administration. Beclobrate reduces LDL-cholesterol and increased HDL… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Benzhydryl CompoundsHypolipidemic Agents

Narrower (1)

Sgd 24774

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1991
1991
Effects of gemfibrozil on serum apolipoprotein E distribution in hypercholesterolemic patients.
1991
1991
Pharmacokinetic studies with the lipid-regulating agent beclobrate: enantiospecific assay for beclobric acid using a new fluorescent chiral coupling component (S-FLOPA).
The major biotransformation pathway for the chiral lipid-regulating agent beclobrate is conversion to the corresponding… 
1990
1990
Beclobrate and liver disease.
To the Editors: A 63-year-old woman died from acute liver failure while being treated with beclobrate, a lipid lowering agent… 
1990
1990
Effective hypolipidaemic therapy with beclobrate in haemodialysis patients: interference with L-carnitine.
The lipid-reducing effects of a new fibric acid derivative (beclobrate, 100 mg/day), L-carnitine (15 mg/ kg b.w. thrice weekly i… 
1987
1987
Induction of peroxisomal fatty acyl-CoA oxidase and microsomal laurate hydroxylase activities by beclobric acid and two metabolites in primary cultures of rat hepatocytes.
1985
1985
[Metabolism of beclobrate in rat and man].
The major pathway of biotransformation of beclobrate [(2-[4-[(4-chlorophenyl)methyl]phenoxy]-2-methylbutyric acid ethyl ester] is… 
1985
1985
Beclobrinic acid--a new hypolipidemic agent--inhibits in vitro human platelet activation by blocking prostaglandin synthesis.
1983
1983
Pharmacological studies with beclobrate, a new hypolipidemic agent.
A new diphenylmethane derivative with potent hypolipidemic activity, ethyl-(+/-)-2-[[alpha-(p-chlorophenyl)-p-tolyl]-oxy]-2… 
1983
1983
Influence of beclobrate on gallstone formation in hamsters.
Three groups of male Syrian hamsters were fed a lithogenic diet (L), L plus 0.04% ethyl-2-[4-(p-chlorophenyl) methylphenoxy]-2… 
1981
1981
Lipid-lowering effect of the new drugs eniclobrate and beclobrate in patients with hyperlipidemia type II a and type II b.
First clinical results are presented for two newly developed drugs. Both are diphenylmethane derivatives named ethyl-(+/-)-2… 
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