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azosemide

Known as: 2-chloro-5-(1H-tetrazole-5-yl)-N^4-(2-thenyl), azosemid, Benzenesulfonamide, 2-chloro-5-(1H-tetrazol-5-yl)-4-((2-thienylmethyl)amino)- 
A monosulfamyl belonging to the class of loop diuretics. Azosemide inhibits sodium and chloride reabsorption throughout the thick ascending limb of… Expand
National Institutes of Health

Papers overview

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2015
2015
Automated molecular de novo design led to the discovery of an innovative inhibitor of death-associated protein kinase 3 (DAPK3… Expand
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2014
2014
The Na+2Cl–K+ cotransporter accepts NH4+ at its K+-binding site. Therefore, the rate of cytosolic acidification after NH4… Expand
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2012
2012
BACKGROUND Diuretics are the most prescribed drug in heart failure (HF) patients. However, clinical evidence about their long… Expand
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2009
2009
Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study… Expand
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Highly Cited
2005
Highly Cited
2005
Human monocarboxylate transporter 6 (MCT6) has recently been isolated, and its tissue distribution has been established at the… Expand
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Review
2003
Review
2003
Azosemide is used in the treatment of oedematous states and hypertension. The exact mechanism of action is not fully understood… Expand
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2003
2003
Defective regulation and/or reduced expression of the Na+-K+-2Cl- cotransporter NKCC1 may contribute to the severe secretory… Expand
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1997
1997
Since considerable first-pass effects of azosemide have been reported after oral administration of the drug to rats and man… Expand
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1984
1984
Teratogenic effects of azosemide, a loop diuretic, were investigated in rats, mice and rabbits. Azosemide was given orally to… Expand
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1979
1979
Azosemide is a new monosulfamyl diuretic which inhibits solute transport throughout the thick ascending limb of the loop of Henle… Expand
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