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azonafide
Known as:
2-(2'-(dimethylamino)ethyl)-1,2-dihydro-3H-dibenz(de,h)isoquinoline-1,3-dione
National Institutes of Health
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Naphthalimides
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2001
2001
Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators
R. Dorr
,
J. Liddil
,
S. M. Sami
,
W. Remers
,
E. Hersh
,
D. Alberts
Anti-Cancer Drugs
2001
Corpus ID: 40413986
The azonafides are a series of anthracene-based DNA intercalators which inhibit tumor cell growth in vitro at low nanomolar…
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1999
1999
Intracellular localization of 6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquino line-1,3-diones (azonafides) is not the limiting factor for their cytotoxicity: an…
C. A. Mayr
,
S. M. Sami
,
W. Remers
,
R. Dorr
Anti-Cancer Drugs
1999
Corpus ID: 24069262
The intracellular localization of 14 structurally unique azonafide analogs was studied to determine if intracellular drug…
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1998
1998
Identification and characterization of in vitro metabolites of 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz [de,h]isoquinoline-1,3-dione (Azonafide).
C. A. Mayr
,
S. M. Sami
,
W. Remers
,
Robert T. Dorr
Drug Metabolism And Disposition
1998
Corpus ID: 24725555
Azonafide (2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de, h]isoquinoline-1,3-dione) is the parent of a new series of…
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1998
1998
IDENTIFICATION AND CHARACTERIZATION OF IN VITRO METABOLITES OF 2-[ 2 *-( DIMETHYLAMINO ) ETHYL ]-1 , 2-DIHYDRO-3 H-DIBENZ
C. A. Mayr
,
S. M. Sami
,
W. Remers
,
R. Dorr
1998
Corpus ID: 32136760
Azonafide (2-[2*-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de, h]isoquinoline-1,3-dione) is the parent of a new series of…
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1997
1997
Mechanistic studies of the cytotoxic action of selected azonafide analogs
C. A. Mayr
1997
Corpus ID: 82293352
1996
1996
2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity…
S. M. Sami
,
Robert T. Dorr
,
David S. Alberts
,
and Anikó M. Sólyom
,
W. Remers
Journal of Medicinal Chemistry
1996
Corpus ID: 7032633
New 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3- diones with substituents at the 4, 8, 9, 10, and 11…
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1996
1996
6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity…
S. M. Sami
,
Robert T. Dorr
,
A. Sólyom
,
David S. Alberts
,
B. S. Iyengar
,
W. Remers
Journal of Medicinal Chemistry
1996
Corpus ID: 33794934
New 2-[2'-(dimethylamino)ethyl]-3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at the 6- and 7-positions were prepared…
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1996
1996
Computer simulation of the binding of amonafide and azonafide to DNA
S. Bear
,
W. Remers
J. Comput. Aided Mol. Des.
1996
Corpus ID: 5217953
SummaryIntercalative binding of the antitumor drugs amonafide and azonafide to the oligonucleotide duplex d(GGCCGGCCGG)·d…
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1995
1995
Amino-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones. Synthesis, antitumor activity, and quantitative structure--activity relationship.
S. M. Sami
,
Robert T. Dorr
,
A. Sólyom
,
David S. Alberts
,
W. Remers
Journal of Medicinal Chemistry
1995
Corpus ID: 43766304
Sets of 2-[2-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones with amino and actylamino groups at each…
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1993
1993
1,2 DYHYDRO-3-H-DIBENZ(de,h) ISOQUINOLINE 1,3-DIONES ET LEUR UTILISATION EN TANT QU'AGENTS ANTICANCEREUX
David S. Alberts
,
R. Dorr
,
William A. Remers
,
S. Sami
1993
Corpus ID: 102936354
L'invention concerne un compose utile pour le traitement des tumeurs represente par la formule (I) dans laquelle, R8, R6 et R10…
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