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aziridine-2,3-dicarboxylate

 
National Institutes of Health

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Broader (1)

Aziridines

Papers overview

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Review
2019
Review
2019
Leishmanicidal therapy targeted to parasite proteases
&NA; Leishmaniasis is considered a serious public health problem and the current available therapy has several disadvantages… Expand
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2018
2018
New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8.
In the present work a series of aziridine-2,3-dicarboxylate inhibitors of papain-like cysteine proteases was designed… Expand
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2015
2015
Development of a New Antileishmanial Aziridine-2,3-Dicarboxylate-Based Inhibitor with High Selectivity for Parasite Cysteine Proteases
ABSTRACT Leishmaniasis is one of the major neglected tropical diseases of the world. Druggable targets are the parasite cysteine… Expand
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2009
2009
Rational design of improved aziridine-based inhibitors of cysteine proteases.
Quantum chemical computations on appropriate model systems are used for a rational design of aziridine-based inhibitors of… Expand
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Highly Cited
2006
Highly Cited
2006
Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.
The protozoan parasite Trypanosoma brucei causes Human African trypanosomiasis, which is fatal if left untreated. Due to the… Expand
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2006
2006
Aziridide‐Based Inhibitors of Cathepsin L: Synthesis, Inhibition Activity, and Docking Studies
A comprehensive screening of N‐acylated aziridine (aziridide) based cysteine protease inhibitors containing either Boc‐Leu‐Caa… Expand
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2004
2004
Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate
Abstract Cysteine proteases have been implicated in a variety of processes essential for the survival and progression of the… Expand
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2000
2000
Aziridinyl peptides as inhibitors of cysteine proteases: effect of a free carboxylic acid function on inhibition.
Peptides containing aziridine-2,3-dicarboxylate (Azi) as electrophilic building block are evaluated as inhibitors of the cysteine… Expand
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