aziridine-2,3-dicarboxylate

Leishmaniasis is one of the major neglected tropical diseases of the world. Druggable targets are the parasite cysteine proteases… (More)

The papain-like cysteine cathepsins expressed by Leishmania play a key role in the life cycle of these parasites, turning them… (More)

Quantum chemical computations on appropriate model systems are used for a rational design of aziridine-based inhibitors of… (More)

The protozoan parasite Trypanosoma brucei causes Human African trypanosomiasis, which is fatal if left untreated. Due to the… (More)

To enable a rational design of improved cysteine protease inhibitors, the present work investigates trends in the inhibition… (More)

A comprehensive screening of N-acylated aziridine (aziridide) based cysteine protease inhibitors containing either Boc-Leu-Caa… (More)

Cysteine proteases have been implicated in a variety of processes essential for the survival and progression of the malarial… (More)

Peptides containing aziridine-2,3-dicarboxylate (Azi) as electrophilic building block are evaluated as inhibitors of the cysteine… (More)