FAQ

attachment of spindle microtubules to kinetochore

Known as: spindle kinetochore attachment, attachment of spindle microtubules to chromosome, microtubule anchoring at kinetochore 
The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. [GOC:vw, PMID:10322137]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
0102019932017

Related topics

Related topics

3 relations

Narrower (2)

attachment of spindle microtubules to kinetochore involved in homologous chromosome segregationmicrotubule binding
regulation of attachment of spindle microtubules to kinetochore

Related mentions per year

Related mentions per year

1980-2018
19801990200020102020
attachment of spindle microtubules to kinetochore
microtubule binding
attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
regulation of attachment of spindle microtubules to kinetochore

Papers overview

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Highly Cited
2011
Highly Cited
2011
Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis.
Precise control of the attachment strength between kinetochores and spindle microtubules is essential to preserve genomic… (More)
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Highly Cited
2011
Highly Cited
2011
Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors.
Most solid tumors are aneuploid, and many missegregate chromosomes at high rates in a phenomenon called chromosomal instability… (More)
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2010
2010
MST1 Limits the Kinase Activity of Aurora B to Promote Stable Kinetochore-Microtubule Attachment
The establishment and maintenance of proper attachment of kinetochores to microtubules are required to prevent chromosome… (More)
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Highly Cited
2008
Highly Cited
2008
Kinetochore-Microtubule Attachment Relies on the Disordered N-Terminal Tail Domain of Hec1
Accurate chromosome segregation is dependent upon stable attachment of kinetochores to spindle microtubules during mitosis. A… (More)
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Highly Cited
2008
Highly Cited
2008
Molecular architecture of the kinetochore-microtubule attachment site is conserved between point and regional centromeres
Point and regional centromeres specify a unique site on each chromosome for kinetochore assembly. The point centromere in budding… (More)
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2008
2008
Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment.
Protein acetylation and deacetylation play key roles in multiple physiological functions. Histone deacetylase 3 (HDAC3) is a… (More)
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Highly Cited
2006
Highly Cited
2006
Molecular architecture of a kinetochore–microtubule attachment site
Kinetochore attachment to spindle microtubule plus-ends is necessary for accurate chromosome segregation during cell division in… (More)
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Highly Cited
2005
Highly Cited
2005
Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites.
A major goal in the study of vertebrate mitosis is to identify proteins that create the kinetochore-microtubule attachment site… (More)
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Highly Cited
2004
Highly Cited
2004
Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle.
The movement of sister chromatids to opposite spindle poles during anaphase depends on the prior capture of sister kinetochores… (More)
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Highly Cited
2002
Highly Cited
2002
Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint.
We have previously identified the opium alkaloid noscapine as a microtubule interacting agent that binds stoichiometrically to… (More)
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