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Centromeres and Kinetochores From Epigenetics to Mitotic Checkpoint Signaling
The centromere is a chromosomal locus that ensures delivery of one copy of each chromosome to each daughter at cell division. Efforts to understand the nature and specification of the centromere have… Expand
Activating and Silencing the Mitotic Checkpoint through CENP-E-Dependent Activation/Inactivation of BubR1
The mitotic checkpoint prevents advance to anaphase prior to successful attachment of every centromere/kinetochore to mitotic spindle microtubules. Using purified components and Xenopus egg extracts,… Expand
ZW10 links mitotic checkpoint signaling to the structural kinetochore
The mitotic checkpoint ensures that chromosomes are divided equally between daughter cells and is a primary mechanism preventing the chromosome instability often seen in aneuploid human tumors. ZW10… Expand
Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling
The mitotic checkpoint is the major cell cycle control mechanism for maintaining chromosome content in multicellular organisms. Prevention of premature onset of anaphase requires activation at… Expand
Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment.
Proper bipolar attachment of sister kinetochores to the mitotic spindle is critical for accurate chromosome segregation in mitosis. Here we show an essential role of the formin mDia3 in achieving… Expand
BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment
The accurate segregation of chromosomes in mitosis requires the stable attachment of microtubules to kinetochores. The details of this complex and dynamic process are poorly understood. In this… Expand
CENP-E–dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint
- Yige Guo, Christine Kim, Sana Ahmad, J. Zhang, Y. Mao
- Biology, Medicine
- The Journal of cell biology
- 23 July 2012
The state of CENP-E–dependent BubR1 autophosphorylation in response to spindle microtubule capture regulates kinetochore function and accurate chromosome segregation.
Diaphanous formin mDia2 regulates CENP-A levels at centromeres
The diaphanous formin mDia2, a protein involved in cytoskeletal control, is required for new CENP-A loading at centromeres during the cell cycle to maintain epigenetic markers.
Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma
- Kelly M. Zullo, Yige Guo, +10 authors O. O’Connor
- Biology, Medicine
- Clinical Cancer Research
- 15 April 2015
Purpose: Aurora A kinase (AAK) is expressed exclusively during mitosis, and plays a critical role in centrosome duplication and spindle formation. Alisertib is a highly selective AAK inhibitor that… Expand
Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2.
The majority of colorectal tumors are aneuploid because of the underlying chromosome instability (CIN) phenotype, in which a defective mitotic checkpoint is implicated. Adenomatous polyposis coli… Expand