atopaxar
National Institutes of Health
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Platelets are the key in the pathogenesis of atherothrombotic disease such as acute coronary syndromes, stroke, and peripheral…
Antiplatelet therapy is used widely with proven benefit for the prevention of further ischemic cardiac complications in patients…
Atopaxar is a reversible protease activated receptor (PAR)-1 thrombin receptor antagonist that interferes with platelet signaling…
Vorapaxar (SCH 530348) and atopaxar (E5555) are oral protease-activated receptor-1 (PAR-1) antagonists with high bioavailability…
Platelets and their activation have a pivotal role in the development of atherosclerotic diseases such as acute myocardial…
Introduction: Platelet activation and reactivity are pivotal for both acute and chronic atherothrombotic event occurrences. Areas…
Aims Two multicentre, randomized, double-blind, placebo-controlled Phase II studies assessed the safety and efficacy of the oral…