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The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs.
Antipruritic Effect of the Topical Phosphodiesterase 4 Inhibitor E6005 Ameliorates Skin Lesions in a Mouse Atopic Dermatitis Model
- N. Ishii, M. Shirato, I. Hishinuma
- Biology, ChemistryThe Journal of Pharmacology and Experimental…
- 1 July 2013
Topical E6005 ameliorated the appearance of atopic dermatitis-like skin lesions in two types of AD models, hapten- and mite-elicited models, exhibiting inhibitory effects comparable to that of tacrolimus.
Involvement of tumor necrosis factor-alpha in the pathogenesis of activated macrophage-mediated hepatitis in mice.
Oral administration of the thrombin receptor antagonist E5555 (atopaxar) attenuates intimal thickening following balloon injury in rats.
Involvement of tumor necrosis factor‐α in development of hepatic injury in galactosamine‐sensitized mice
Intravenous injection of lipopolysaccharide and D‐galactosamine, at doses of 0.2 μg/kg and 800 mg/kg, respectively, elicited massive hepatic necrosis within 24 hr in C3H/HeN mice. The plasma…
Mechanism of growth promotion of mouse lymphoma L1210 cells in vitro by feeder layer or 2‐mercaptoethanol
The deficiency of the cystine uptake limits the growth of L1210 cells in normal culture media and shows that the major role of feeder layer cells is to provide cysteine continuously.
[Effects of E-3123, a new protease inhibitor, on several protease activities and on experimental acute pancreatitis].
- K. Miyamoto, I. Hishinuma, J. Nagakawa, N. Nagaoka, T. Yamanaka, T. Wakabayashi
- Biology, MedicineNihon yakurigaku zasshi. Folia pharmacologica…
- 1 May 1988
The results show that E-3123 may possess suppressing effects on pathogenesis and development of acute pancreatitis and in dogs with pancreatitis, increases in serum trypsin and lipase activities were significantly reduced by infusion of E- 3123.
Protective effects of (2E)-3-[5-(2,3-dimethoxy-6-methyl-1,4- benzoquinoyl)]-2-nonyl-2-propenoic acid on endotoxin-mediated hepatitis in mice.
- J. Nagakawa, I. Hishinuma, I. Yamatsu
- Chemistry, BiologyThe Journal of pharmacology and experimental…
- 1 July 1992
Oral pretreatment with E3330 attenuated the elevation of plasma tumor necrosis factor activity and protected mice from liver injury and inhibited the production of tumor Necrosis factor from cultured Propionibacterium acnes-elicited murine peritoneal macrophages on stimulation with lipopolysaccharide in vitro.
Alpha-tocopherol and inhibition of cytolysis in glutathione-depleted hepatocytes in primary culture.
- I. Hishinuma, T. Nakamura
- Biology, MedicineJournal of nutritional science and vitaminology
- 1 February 1988
The results suggest that alpha-tocopherol may be a primary natural inhibitor of the cytolysis induced by xenobiotics which consume the cellular GSH in vivo.
Protective effect of E3330, a novel quinone derivative, in galactosamine-induced hepatitis in rats.
- J. Nagakawa, K. Hirota, I. Yamatsu
- Biology, ChemistryThe Journal of pharmacology and experimental…
The results suggest that E3330 may exert its hepatoprotective effects through inhibition of an effect of endotoxin in galactosamine-induced hepatitis in rats.