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Transgene expression in vivo for therapeutic purposes will require methods that allow for efficient gene transfer into cells… Expand Our previous isothermal titration microcalorimetry (ITC) studies of the binding of synthetic multivalent carbohydrates to the Man… Expand A novel lipidic vector composed of DOTAP/Chol liposomes, asialofetuin (AF), protamine sulfate and DNA has been developed. The… Expand The asialoglycoprotein receptor (ASGP-R) on mammalian hepatocytes provides a unique means for the development of liver-specific… Expand We have evaluated the effect of NaCl concentration on the mode of binding of poly-l-lysine to DNA and the resulting structural… Expand To improve liposome‐directed therapy of liver disease and gene delivery, it would be beneficial to selectively target hepatocytes… Expand Plant and animal lectins bind and cross-link certain multiantennary oligosaccharides, glycopeptides, and glycoproteins. This can… Expand We recently developed a general method for determining tissue sites of degradation of plasma proteins in vivo that made use of… Expand Galactose-terminating ligands are specifically recognized by mammalian hepatocytes, internalized, and degraded within lysosomes… Expand The capacity of the liver to eliminate asialofetuin and asialoorosomucoid was investigated in intact rats. From plasma… Expand