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ascofuranone

National Institutes of Health

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Sesquiterpenes

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Highly Cited
2019
Highly Cited
2019
Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum
Significance Ascofuranone (AF) and ascochlorin (AC) are fungal natural products with similar chemical structures, originally… 
Highly Cited
2010
Highly Cited
2010
Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex.
Highly Cited
2010
Highly Cited
2010
Purification and kinetic characterization of recombinant alternative oxidase from Trypanosoma brucei brucei.
Highly Cited
2006
Highly Cited
2006
Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms.
The expression of matrix metalloproteinase-9 (MMP-9) has been implicated in the invasion and metastasis of cancer cells. Here, we… 
Review
2004
Review
2004
Direct evidence for cyanide-insensitive quinol oxidase (alternative oxidase) in apicomplexan parasite Cryptosporidium parvum: phylogenetic and therapeutic implications.
2003
2003
Purification of active recombinant trypanosome alternative oxidase
1988
1988
Antitumor and antimetastatic activity of an antibiotic, ascofuranone, and activation of phagocytes.
Ascofuranone demonstrated antitumor activity against FM3A murine mammary carcinoma, implanted in the peritoneal cavity of… 
1986
1986
In vitro effects of an antitumor antibiotic, ascofuranone, on the murine immune system.
Effects of an antitumor antibiotic, ascofuranone (AF) on the murine immune system were studied. Unlike lectins, AF did not induce… 
1981
1981
Unusual concentration of urine and prevention of polydipsia by fungal prenylphenols in DOCA hypertensive rats.
Highly Cited
1973
Highly Cited
1973
Isolation and structure of ascofuranone and ascofranol, antibiotics with hypolipidemic activity.
A new antibiotic with hypolipidemic activity, ascofuranone, C23H29C1O5, and related substance, ascofuranol, C23H31C1O5, were… 
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