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artelinic acid

Known as: sodium artelinate 
National Institutes of Health

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Artemisinins

Papers overview

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2007
2007
Neurotoxicity and Toxicokinetics of Artelinic Acid Following Repeated Oral Administration in Rats
Neurotoxicity secondary to oil-soluble artemisinins has been reported in various animal species. The onset of neurotoxicity and… 
2004
2004
Development of a reversed-phase thin-layer chromatographic method for artemisinin and its derivatives.
In this study a clear separation between seven analogues of artemisinin on thin-layer chromatography (TLC) is presented. The… 
2002
2002
Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents.
Short chemical syntheses of four new antimalarial trioxanes are presented, starting with inexpensive and commercially available… 
1997
1997
Antimalarial activity of new dihydroartemisinin derivatives. 7. 4-(p-substituted phenyl)-4(R or S)-[10(alpha or beta)-dihydroartemisininoxy]butyric acids.
To search for water soluble dihydroartemisinin derivatives with higher efficacy and longer plasma half-life than artesunic or… 
1997
1997
Biomimetic Metabolism of Artelinic Acid by Chemical Cytochrome P-450 Model Systems
AbstractPurpose. To study the reaction of artelinic acid with chemical model systems of cytochrome P-450 as a means of obtaining… 
Highly Cited
1995
Highly Cited
1995
Antimalarial activity of new dihydroartemisinin derivatives. 6. alpha-Alkylbenzylic ethers.
A series of diastereomeric dihydroartemisinin alpha-alkylbenzylic ethers was synthesized in search for analogs with higher… 
1994
1994
Antimalarial activity of dihydroartemisinin derivatives by transdermal application.
In addition to artelinic acid, which was demonstrated previously to possess good prophylactic as well as curative antimalarial… 
1992
1992
Hepatic metabolism of artemisinin drugs--III. Induction of hydrogen peroxide production in rat liver microsomes by artemisinin drugs.
1991
1991
Transdermal artelinic acid: an effective treatment for Plasmodium berghei-infected mice.
Artelinic acid, a derivative of the naturally occurring antimalarial artemisinin, has been incorporated into a gel suitable for… 
1990
1990
Plasmodium berghei: the antimalarial action of artemisinin and sodium artelinate in vivo and in vitro, studied by flow cytometry.
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