artelinic acid

The artemisinin antimalarials cause embryo death and malformations in animals by killing embryonic erythroblasts. Groups of… (More)

Amplification of the Plasmodium falciparum multidrug resistance 1 gene (pfmdr1) has been implicated in multidrug resistance… (More)

Artemisinin and its derivatives are the most rapidly acting and efficacious antimalarial drugs currently available. Although… (More)

Neurotoxicity secondary to oil-soluble artemisinins has been reported in various animal species. The onset of neurotoxicity and… (More)

The sporontocidal activity of tafenoquine (WR-238605) and artelinic acid was determined against naturally circulating isolates of… (More)

In only two steps and in 70% overall yield, naturally occurring trioxane artemisinin (1) was converted on a gram scale into C-10… (More)

The pharmacokinetics and bioavailability of dihydroartemisinin (DQHS), artemether (AM), arteether (AE), artesunic acid (AS) and… (More)

The pharmacokinetics, metabolism, protein binding, red blood cell (RBC) binding, stability in vitro, and acute and anorectic… (More)

Purpose. To study the reaction of artelinic acid with chemical model systems of cytochrome P-450 as a means of obtaining… (More)

The speed and stage specificity of antimalarial drug action on the metabolic activities of cultured Plasmodium falciparum were… (More)