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External genitalia abnormalities in male rats exposed in utero to finasteride, a 5 alpha-reductase inhibitor.
TLDR
A series of studies was conducted to determine the developmental toxicity of the 5 alpha-reductase inhibitor finasteride (MK-0906) in rats, finding that the enzymatic proteins in the genital tubercle and ventral prostate may be similar.
Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit.
TLDR
Investigations of the mechanism of developmental toxicity are ongoing to attempt to determine whether rats and rabbits are more sensitive to artemisinins than humans, and no adverse drug-related developmental effects have been observed in a limited number of pregnant women treated with artesinins, primarily artesunate.
Diet, Overfeeding, and Moderate Dietary Restriction in Control Sprague-Dawley Rats: II. Effects on Age-Related Proliferative and Degenerative Lesions
TLDR
The conclusion from this study is that moderate DR delayed onset and progression of degenerative lesions, and death due to cardiovascular or renal disease, and thus potentially improves the bioassay to detect compound-specific chronic toxicity.
Diet, Overfeeding, and Moderate Dietary Restriction in Control Sprague-Dawley Rats: I. Effects on Spontaneous Neoplasms
This study was designed to compare the effects of ad libitum (AL) overfeeding and moderate dietary restriction (DR) of two different diets on Sprague-Dawley (SD) rat 2-yr survival and the development
Artesunate-induced depletion of embryonic erythroblasts precedes embryolethality and teratogenicity in vivo.
TLDR
Embryos were viable through Day 13 pc, but approximately 77% of embryos had died by Day 14 pc, presumably due to hypoxia and/or cardiac abnormalities.
A microfluidic device and computational platform for high throughput live imaging of gene expression
TLDR
A microfluidics device, the RootArray, in which 64 Arabidopsis thaliana seedlings can be grown and their roots imaged by confocal microscopy over several days without manual intervention, and decoupled acquisition from analysis to achieve high throughput.
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