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arildone

Known as: 3,5-Heptanedione, 4-(6-(2-chloro-4-methoxyphenoxy)hexyl)-, 4-(6-(2-Chloro-4-methoxyphenoxy)hexyl)-3,5-heptanedione, 4-(6-(2-chloro-4-methoxy)phenoxy)hexyl-3,5-heptanedione 
A novel aryl diketone with activity against both DNA and RNA viruses. Arildone interacts directly with the poliovirus capsid and prevents uncoating… 
National Institutes of Health

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2 relations

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Antiviral AgentsKetones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1989
1989
The synthesis of novel pyrophosphate analogues and their antiviral activities
Several methods for the preparation of novel substituted methylene-bisphosphonates were examined. A new synthesis of… 
1987
1987
Effects of arildone on the immunogenicity of formalin-inactivated polioviruses.
Concentrated and purified Sabin and virulent strains of poliovirus types 1, 2 and 3 were inactivated with formalin at 37 C. By… 
1987
1987
Studies on the arildone class of antiviral agents
1985
1985
Tolerance and Percutaneous Absorption of Topically Applied Arildone
Arildone, an investigational antiviral agent, was compared to both its vanishing cream and 90% dimethyl sulfoxide (DMSO) solution… 
1985
1985
Activity of arildone with or without interferon against acute hemorrhagic conjunctivitis viruses in cell culture
Arildone (WIN 38020; 4-[6-(2-chloro-4-methoxyphenoxy)hexyl]-3,5-heptanedione) inhibited the infectivity of acute hemorrhagic… 
1984
1984
Effect of dichloroflavan (BW683C) on the stability and uncoating of rhinovirus type 1B.
Dichloroflavan was found to stabilize rhinovirus 1B to inactivation by heat at 56 degrees C or by acid at pH 4.6 to 5.0. The… 
1984
1984
Protein kinase activity in purified poliovirus particles and empty viral capsid preparations.
Preparations of purified poliovirus type 1, strain Mahoney, and empty viral capsids contain a protein kinase activity. The gamma… 
1984
1984
DTECTION OF ENTEROVIRUSES BY DNA-RNA DOT HYBRIDIZATION–PROGRESS TOWARD A RAPID DIAGNOSIS
The antigenic heterogeneity among the more than 70 serotypes of enteroviruses has been the major obstacle to rapid diagnosis of… 
1982
1982
Disposition of arildone, an antiviral agent, after various routes of administration
[14C]arildone was administered both topically and intravaginally to mice 5 times a day for 7 days to simulate conditions of… 
1979
1979
Preliminary Studies of the Mode of Action of Arildone, a Novel Antiviral Agent
Arildone (also known as Win 38020), a novel aryl diketone, inhibited replication of herpes simplex virus type 2 in tissue culture… 
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