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argadin

Known as: cyclo(N(omega)-acetyl-L-arginyl-D-prolyl-homoseryl-histidyl-L- 2-aminoadipyl) 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Cyclic Peptides

Papers overview

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2011
2011
Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage.
Acidic mammalian chitinase (AMCase) is an enzyme that selectively degrades the biopolymer chitin. Several chitinase enzymes are… Expand
2010
2010
Structure of the O-antigen of Acinetobacter lwoffii EK30A; identification of d-homoserine, a novel non-sugar component of bacterial polysaccharides.
We established a peculiar structure of the O-specific polysaccharide (O-antigen) of a psychrotrophic strain of Acinetobacter… Expand
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2009
2009
Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin
A versatile solid-phase total synthesis was applied to the rapid preparation of Argadin, a natural product isolated and… Expand
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2008
2008
Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens.
Molecular dynamics (MD) simulations and the molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) method were applied to… Expand
2007
2007
Discovery, chemistry, and chemical biology of microbial products
Our long-standing and continual screening of microorganisms, especially for antiparasitic agents, has produced a wide variety of… Expand
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2006
2006
First Synthesis of Argadin: A Nanomolar Inhibitor of Family‐18 Chitinases
The first synthesis of the cyclic peptide natural product, argadin is reported. Use of a solid-phase approach featuring side… Expand
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Highly Cited
2005
Highly Cited
2005
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.
Family 18 chitinases play key roles in organisms ranging from bacteria to man. There is a need for specific, potent inhibitors to… Expand
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Highly Cited
2004
Highly Cited
2004
Structure-based exploration of cyclic dipeptide chitinase inhibitors.
Family 18 chitinases play an essential role in a range of pathogens and pests. Several inhibitors are known, including the potent… Expand
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Highly Cited
2002
Highly Cited
2002
High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: Mimicry of carbohydrate substrate
Over the past years, family 18 chitinases have been validated as potential targets for the design of drugs against human… Expand
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Highly Cited
2000
Highly Cited
2000
Argadin, a new chitinase inhibitor, produced by Clonostachys sp. FO-7314.
A new chitinase inhibitor, designated as argadin (1), was isolated from the cultured broth of a fungal strain FO-7314. The strain… Expand
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