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arachidonate 15-lipoxygenase activity

Known as: arachidonate omega6 lipoxygenase activity, arachidonate omega(6) lipoxygenase activity, linoleic acid omega6-lipoxygenase activity 
Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. [EC:1.13.11.33]
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation.
Estrogen replacement therapy has been associated with reduction of cardiovascular events in postmenopausal women, though the… Expand
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Highly Cited
1996
Highly Cited
1996
Activation of NADPH oxidase required for macrophage-mediated oxidation of low-density lipoprotein.
Low-density lipoprotein (LDL) oxidation by arterial wall cells, a key event during early atherogenesis, was suggested to involve… Expand
Highly Cited
1995
Highly Cited
1995
Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.
Oxidized low density lipoprotein (LDL) possesses several atherogenic properties. The mechanisms by which LDL becomes oxidized in… Expand
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Highly Cited
1993
Highly Cited
1993
Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease.
We have previously described the distribution of the arachidonate 15-lipoxygenase in lung tissue obtained from healthy human… Expand
Highly Cited
1992
Highly Cited
1992
Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.
The oxidative modification of low density lipoprotein (LDL) may play an important role in the pathogenesis of atherosclerosis… Expand
Highly Cited
1990
Highly Cited
1990
Endothelin-1 stimulates arachidonate 15-lipoxygenase activity and oxygen radical formation in the rat distal lung.
We investigated the effects of intravenous bolus of endothelin-1 on the metabolism of eicosanoids and oxygen radicals in the… Expand
Highly Cited
1990
Highly Cited
1990
Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related.
Cloned 15-lipoxygenase has been expressed for the first time in eukaryotic and prokaryotic cells. Transfection of osteosarcoma… Expand
Highly Cited
1989
Highly Cited
1989
Anti-inflammatory drugs in experimental atherosclerosis. 7. Spontaneous atherosclerosis in WHHL rabbits and inhibition by cortisone acetate.
The Watanabe heritable hyperlipidemic (WHHL) rabbit, an animal model for familial hypercholesterolemia, has a deficiency in low… Expand
Highly Cited
1986
Highly Cited
1986
Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo.
Ketoconazole inhibits in vitro (IC50:2.6 X 10(-5) M) the formation of 5-HETE and LTB4 by isolated, carrageenin-elicited rat… Expand
1985
1985
Selective expression of 15-lipoxygenase activity by cultured human keratinocytes.
Human keratinocytes isolated from neonatal skin express 15-lipoxygenase activity at a level far greater than that of any of the… Expand
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