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arachidonate 15-lipoxygenase activity

Known as: arachidonate omega6 lipoxygenase activity, arachidonate omega(6) lipoxygenase activity, linoleic acid omega6-lipoxygenase activity 
Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. [EC:1.13.11.33]
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection
Significance We provide evidence for a functional role of bioactive lipid mediators of the docosapentaenoic acid (DPA) metabolome… 
Highly Cited
2002
Highly Cited
2002
Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation.
Estrogen replacement therapy has been associated with reduction of cardiovascular events in postmenopausal women, though the… 
Highly Cited
1996
Highly Cited
1996
Activation of NADPH oxidase required for macrophage-mediated oxidation of low-density lipoprotein.
Highly Cited
1995
Highly Cited
1995
Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.
Oxidized low density lipoprotein (LDL) possesses several atherogenic properties. The mechanisms by which LDL becomes oxidized in… 
Highly Cited
1993
Highly Cited
1993
Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease.
We have previously described the distribution of the arachidonate 15-lipoxygenase in lung tissue obtained from healthy human… 
Highly Cited
1992
Highly Cited
1992
Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.
The oxidative modification of low density lipoprotein (LDL) may play an important role in the pathogenesis of atherosclerosis… 
Highly Cited
1990
Highly Cited
1990
Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related.
Highly Cited
1989
Highly Cited
1989
Anti-inflammatory drugs in experimental atherosclerosis. 7. Spontaneous atherosclerosis in WHHL rabbits and inhibition by cortisone acetate.
Highly Cited
1988
Highly Cited
1988
Uptake, release and novel species-dependent oxygenation of arachidonic acid in human and animal airway epithelial cells.
Highly Cited
1986
Highly Cited
1986
Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo.
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