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arachidonate 15-lipoxygenase activity
Known as:
arachidonate omega6 lipoxygenase activity
, arachidonate omega(6) lipoxygenase activity
, linoleic acid omega6-lipoxygenase activity
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Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. [EC:1.13.11.33]
National Institutes of Health
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Highly Cited
2017
Highly Cited
2017
Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection
T. Gobbetti
,
J. Dalli
,
+9 authors
M. Perretti
Proceedings of the National Academy of Sciences
2017
Corpus ID: 205282446
Significance We provide evidence for a functional role of bioactive lipid mediators of the docosapentaenoic acid (DPA) metabolome…
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Highly Cited
2002
Highly Cited
2002
Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation.
M. Maccarrone
,
M. Bari
,
N. Battista
,
A. Finazzi-Agro’
Blood
2002
Corpus ID: 22559309
Estrogen replacement therapy has been associated with reduction of cardiovascular events in postmenopausal women, though the…
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Highly Cited
1996
Highly Cited
1996
Activation of NADPH oxidase required for macrophage-mediated oxidation of low-density lipoprotein.
M. Aviram
,
M. Rosenblat
,
Amos Etzioni
,
R. Levy
Metabolism: clinical and experimental
1996
Corpus ID: 34521900
Highly Cited
1995
Highly Cited
1995
Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.
S. Ylä-Herttuala
,
J. Luoma
,
H. Viita
,
T. Hiltunen
,
T. Sisto
,
T. Nikkari
The Journal of clinical investigation
1995
Corpus ID: 32361310
Oxidized low density lipoprotein (LDL) possesses several atherogenic properties. The mechanisms by which LDL becomes oxidized in…
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Highly Cited
1993
Highly Cited
1993
Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease.
V. Shannon
,
P. Chanez
,
J. Bousquet
,
M. Holtzman
The American review of respiratory disease
1993
Corpus ID: 23237210
We have previously described the distribution of the arachidonate 15-lipoxygenase in lung tissue obtained from healthy human…
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Highly Cited
1992
Highly Cited
1992
Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.
C. Sparrow
,
J. Olszewski
Proceedings of the National Academy of Sciences…
1992
Corpus ID: 7641957
The oxidative modification of low density lipoprotein (LDL) may play an important role in the pathogenesis of atherosclerosis…
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Highly Cited
1990
Highly Cited
1990
Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related.
E. Sigal
,
D. Grunberger
,
E. Highland
,
C. Gross
,
R. Dixon
,
C. Craik
The Journal of biological chemistry
1990
Corpus ID: 45273693
Highly Cited
1989
Highly Cited
1989
Anti-inflammatory drugs in experimental atherosclerosis. 7. Spontaneous atherosclerosis in WHHL rabbits and inhibition by cortisone acetate.
A. Makheja
,
S. Bloom
,
R. Muesing
,
T. Simon
,
J. M. Bailey
Atherosclerosis
1989
Corpus ID: 45207882
Highly Cited
1988
Highly Cited
1988
Uptake, release and novel species-dependent oxygenation of arachidonic acid in human and animal airway epithelial cells.
M. Holtzman
,
J. R. Hansbrough
,
G. Rosen
,
J. Turk
Biochimica et biophysica acta
1988
Corpus ID: 23568391
Highly Cited
1986
Highly Cited
1986
Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo.
J. Beetens
,
W. Loots
,
Y. Somers
,
M. Coene
,
F. De Clerck
Biochemical pharmacology
1986
Corpus ID: 40658308
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