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Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex.
TLDR
Findings support an anxiolytic role for physiological increases in AEA in the PFC, whereas more marked increases or decreases of this endocannabinoid might lead to an anxiogenic response due to TRPV1 stimulation or the lack of CB1 activation, respectively.
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Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum
TLDR
It is found that stimulation of metabotropic glutamate 5 receptors by 3,5-dihydroxyphenylglycine (DHPG) depressed inhibitory transmission in the striatum through selective involvement of 2-AG metabolism and stimulation of presynaptic CB1 receptors.
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Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
TLDR
The data presented indicate a protective role of cannabinoid receptors against apoptosis induced by AEA via vanilloid receptors, and other endocannabinoids such as 2-arachidonoylglycerol, linoleoylethanolamide, oleoylethanlamide, and palmitoyle Thanolamide did not promote cell death under the same experimental conditions.
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Experimental Parkinsonism Alters Endocannabinoid Degradation: Implications for Striatal Glutamatergic Transmission
TLDR
In a rat model of Parkinson's disease induced by unilateral nigral lesion with 6-hydroxydopamine, the striatal levels of anandamide, but not that of the other endocannabinoid 2-arachidonoylglycerol, were increased, and inhibition of an andamide hydrolysis might represent a possible target to decrease the abnormal cortical glutamatergic drive in Parkinson’s disease.
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Jekyll and hyde: two faces of cannabinoid signaling in male and female fertility.
TLDR
A wealth of information on the significance of cannabinoid/endocannabinoid signaling in spermatogenesis, fertilization, preimplantation embryo development, implantation, and postim implantation embryonic growth has been generated.
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Endocannabinoid signaling at the periphery: 50 years after THC.
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The Activity of Anandamide at Vanilloid VR1 Receptors Requires Facilitated Transport across the Cell Membrane and Is Limited by Intracellular Metabolism*
TLDR
The CB1 receptor antagonist SR141716A inhibited also the VR1-mediated effect of anandamide and capsaicin on cytosolic Ca2+ concentration, although at concentrations higher than those required for CB1 antagonism.
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Presynaptic Facilitation of Glutamatergic Synapses to Dopaminergic Neurons of the Rat Substantia Nigra by Endogenous Stimulation of Vanilloid Receptors
TLDR
A tonic facilitation of glutamate release exerted by VR1 in the SNc through a stimulation of VR1 by endovanilloids, including anandamide is suggested, which suggests the involvement of these receptors in motor and cognitive functions involving the dopaminergic system.
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Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction
TLDR
It is shown that sperm cells have a complete and efficient endocannabinoid system, and that activation of cannabinoid or vanilloid receptors controls, at different time-points, sperm functions required for fertilization.
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Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses
TLDR
D-series resolvins and maresin 1 modulate adaptive immune responses in human peripheral blood lymphocytes and reduce cytokine production by activated CD8+ T cells and CD4+ T helper 1 (TH1) and TH17 cells but do not modulate T cell inhibitory receptors or abrogate their capacity to proliferate.
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