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aprinocarsen

 
National Institutes of Health

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2011
2011
  • Dan Jones
  • Nature Reviews Drug Discovery
  • 2011
  • Corpus ID: 20584545
Antisense therapy has generated waves of enthusiasm and disappointment. With a new drug about to be submitted for approval, is it… Expand
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Highly Cited
2006
Highly Cited
2006
PURPOSE To determine whether aprinocarsen, an antisense oligonucleotide directed against protein kinase C-alpha, when added to… Expand
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2006
2006
Summary The antisense oligonucleotide aprinocarsen specifically inhibits the transcription of protein kinase C-α. This study… Expand
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2006
2006
The antisense oligonucleotide aprinocarsen specifically inhibits the transcription of protein kinase C-alpha. This study… Expand
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2005
2005
Protein kinase C alpha (PKC-alpha) is a cytoplasmic serine threonine kinase involved in regulating cell differentiation and… Expand
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2005
2005
SummaryAprinocarsen is a specific antisense oligonucleotide inhibitor of protein kinase C-α. This study aimed to evaluate the… Expand
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2005
2005
Purpose: A phase I study was performed to determine the maximum tolerated dose (MTD), safety profile and pharmacology of… Expand
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2005
2005
7053 Background: Aprinocarsen (Ap; Affinitak) is an antisense oligonucleotide tailored to target PKCα mRNA, thereby inhibiting… Expand
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2004
2004
BACKGROUND It has been postulated that protein kinase C alpha (PKC-alpha) plays a pivotal role in signal transduction in tumor… Expand
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Review
2003
Review
2003
Antisense oligonucleotides (ASOs) offer a novel pharmacological platform to develop highly specific drugs. As shown by the… Expand
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