aprinocarsen

 

Topic mentions per year

Topic mentions per year

2003-2016
012320032016

Papers overview

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2006
2006
PURPOSE To determine whether aprinocarsen, an antisense oligonucleotide directed against protein kinase C-alpha, when added to… (More)
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2006
2006
The antisense oligonucleotide aprinocarsen specifically inhibits the transcription of protein kinase C-alpha. This study… (More)
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2005
2005
Protein kinase C alpha (PKC-alpha) is a cytoplasmic serine threonine kinase involved in regulating cell differentiation and… (More)
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2005
2005
Aprinocarsen is a specific antisense oligonucleotide inhibitor of protein kinase C-α. This study aimed to evaluate the response… (More)
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2005
2005
Purpose: A phase I study was performed to determine the maximum tolerated dose (MTD), safety profile and pharmacology of… (More)
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2004
2004
BACKGROUND It has been postulated that protein kinase C alpha (PKC-alpha) plays a pivotal role in signal transduction in tumor… (More)
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Review
2004
Review
2004
Antisense oligonucleotide (ASO) technology offers a novel approach for the development of anti-cancer drugs. For example, the ASO… (More)
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Review
2004
Review
2004
As our understanding of tumorigenesis increases, interference with the various signaling pathways of tumor cells has become an… (More)
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Review
2004
Review
2004
Drugs specifically designed to block cellular signalling proteins are currently evaluated as a new way to treat gastrointestinal… (More)
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Review
2003
Review
2003
Antisense oligonucleotides (ASOs) offer a novel pharmacological platform to develop highly specific drugs. As shown by the… (More)
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