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aprinocarsen

National Institutes of Health

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Phosphorothioate Oligonucleotides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Effects of sodium lactate Ringer's injection on transfection of human protein kinase C-α antisense oligonucleotide in A549 lung cancer cells.
In the present study, we evaluated the effects of four solutions [Dulbecco's modified Eagle's medium (DMEM), sodium lactate… 
2008
2008
Dose-dense chemotherapy with trastuzumab is an appropriate option.
2839, 2005 11. Paz-Ares L, Douillard JY, Koralewski P, et al: Phase III study of gemcitabine and cisplatin with or without… 
Review
2007
Review
2007
Enzastaurin , a Protein Kinase C B ^ Selective Inhibitor , and Its PotentialApplicationasanAnticancer AgentinLungCancer
Enzastaurin, an oral serine/threonine kinase inhibitor, suppresses signaling throughprotein kinase C (PKC)-h and the… 
2006
2006
Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer.
The antisense oligonucleotide aprinocarsen specifically inhibits the transcription of protein kinase C-alpha. This study… 
2005
2005
Randomized phase III trial of gemcitabine/cisplatin (GC) and protein kinase C α (PKCα) antisense oligonucleotide aprinocarsen in patients (pts) with advanced stage non-small cell lung cancer (NSCLC)
7053 Background: Aprinocarsen (Ap; Affinitak) is an antisense oligonucleotide tailored to target PKCα mRNA, thereby inhibiting… 
2005
2005
O-085 Phase III trial of the protein kinase C α (PKCα) antisense oligonucleotide Aprinocarsen plus gemcitabine/cisplatin versus gemcitabine/cisplatin alone in advanced stage non-small cell lung…
Review
2004
Review
2004
The role of protein kinase C-alpha in malignancies of the nervous system and implications for the clinical development of the specific PKC-alpha inhibitor aprinocarsen (Review).
Antisense oligonucleotide (ASO) technology offers a novel approach for the development of anti-cancer drugs. For example, the ASO… 
2004
2004
Aprinocarsen/cisplatin/gemcitabine may have activity in NSCLC
  • 2004
  • Corpus ID: 195148347
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