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apricitabine

Known as: 2(1H)-Pyrimidinone, 4-amino-1-((2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl)- 
A cytidine analogue and nucleoside reverse transcriptase inhibitor (NRTI) with anti-HIV activity. Apricitabine is effective against nucleoside… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

(-)-BCH 10652SPD754

Broader (1)

Deoxycytidine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Meeting report: 26th International Conference on Antiviral Research☆
Highly Cited
2011
Highly Cited
2011
Scientific Report: Highlights of 24th ICAR, 8–11 May 2011, Sofia, Bulgaria
The 24th ICAR meeting was held in Sofia, Bulgaria, 8–11 May 2011. This report summarizes the presentations by the ICAR award… 
Review
2010
Review
2010
Resistance profile of the new nucleoside reverse transcriptase inhibitor apricitabine.
Apricitabine is a novel deoxycytidine nucleoside reverse transcriptase inhibitor (NRTI) currently in clinical development for the… 
2007
2007
In Vitro Interactions between Apricitabine and Other Deoxycytidine Analogues
ABSTRACT Apricitabine is a novel deoxycytidine analogue reverse transcriptase inhibitor that is under development for the… 
2007
2007
Effect of Lamivudine on the Plasma and Intracellular Pharmacokinetics of Apricitabine, a Novel Nucleoside Reverse Transcriptase Inhibitor, in Healthy Volunteers
ABSTRACT Apricitabine is a novel deoxycytidine analog reverse transcriptase inhibitor. In vitro apricitabine competes with other… 
2007
2007
Kinetics of Inhibition of HIV Type 1 Reverse Transcriptase-Bearing NRTI-associated Mutations by Apricitabine Triphosphate
We wished to investigate the effects of various mutations in HIV-1 reverse transcriptase (RT) on biochemical inhibition by the… 
Review
2007
Review
2007
Apricitabine: A Novel Deoxycytidine Analogue Nucleoside Reverse Transcriptase Inhibitor for the Treatment of Nucleoside-Resistant HIV Infection
Existing nucleoside reverse transcriptase inhibitors for HIV disease are limited by problems of resistance and, in some cases… 
2006
2006
Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients
Objective:Apricitabine (formerly AVX754 and SPD754) is a deoxycytidine analogue nucleoside reverse transcriptase inhibitor in… 
2006
2006
Pharmacokinetics of Single Oral Doses of Apricitabine, a Novel Deoxycytidine Analogue Reverse Transcriptase Inhibitor, in Healthy Volunteers
AbstractBackground: Apricitabine is a novel deoxycytidine analogue reverse transcriptase inhibitor that is undergoing clinical… 
2006
2006
Effects of Trimethoprim on the Clearance of Apricitabine, a Deoxycytidine Analog Reverse Transcriptase Inhibitor, and Lamivudine in the Isolated Perfused Rat Kidney
Apricitabine (ATC) is a novel deoxycytidine analog reverse transcriptase inhibitor in development for the treatment of human… 
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