Resistance profile of the new nucleoside reverse transcriptase inhibitor apricitabine.

@article{Cahn2010ResistancePO,
  title={Resistance profile of the new nucleoside reverse transcriptase inhibitor apricitabine.},
  author={Pedro E. Cahn and Mark A. Wainberg},
  journal={The Journal of antimicrobial chemotherapy},
  year={2010},
  volume={65 2},
  pages={213-7}
}
Apricitabine is a novel deoxycytidine nucleoside reverse transcriptase inhibitor (NRTI) currently in clinical development for the treatment of HIV infection. Apricitabine shows antiviral activity in vitro against HIV-1 strains and clinical isolates with mutations in the reverse transcriptase that confer resistance to other NRTIs, including M184V, thymidine analogue mutations (TAMs), nucleoside-associated mutations such as L74V and certain mutations at codon 69. Apricitabine has shown activity… CONTINUE READING
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