androstane
National Institutes of Health
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Constitutive androstane receptor (CAR, NR1I3), which is under consideration in this review, is a member of the superfamily of…
ATP-driven efflux transporters at the blood-brain barrier both protect against neurotoxicants and limit drug delivery to the…
CYP2B6 is mainly expressed in the liver that has been thought historically to play an insignificant role in human drug metabolism…
Altered DNA methylation is an epigenetic mechanism that plays a key role in the carcinogenesis process, and the nongenotoxic…
UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates endogenous metabolites, such as bilirubin, and exogenous substances, and…
Lipid homeostasis is controlled by various nuclear receptors (NRs), including the peroxisome proliferator-activated receptors…
The constitutive androstane receptor (CAR) NR1I3 is a transcription factor that upon activation by xenobiotics induces…
The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mediate the expression of mammalian cytochrome p450…
The CYP2C subfamily metabolizes many clinically important drugs. These genes respond to prototypical inducers such as…
The orphan receptor CAR-β (ref. 1) binds DNA as a heterodimer with the retinoid-X receptor and activates gene transcription in a…