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androstane

 
National Institutes of Health

Papers overview

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2015
2015
The constitutive androstane receptor (CAR) modulates the transcription of numerous genes involving drug metabolism, energy… Expand
Highly Cited
2010
Highly Cited
2010
ATP-driven efflux transporters at the blood-brain barrier both protect against neurotoxicants and limit drug delivery to the… Expand
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Highly Cited
2009
Highly Cited
2009
Di-(2-ethylhexyl)-phthalate (DEHP), a widely used plasticizer, is detected in consumer's body fluids. Contamination occurs… Expand
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Highly Cited
2005
Highly Cited
2005
UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates endogenous metabolites, such as bilirubin, and exogenous substances, and… Expand
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Highly Cited
2004
Highly Cited
2004
The constitutive androstane receptor (CAR) NR1I3 is a transcription factor that upon activation by xenobiotics induces… Expand
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Highly Cited
2004
Highly Cited
2004
Human constitutive androstane (or active) receptor (hCAR), a member of the nuclear receptor superfamily NR1I3, regulates the… Expand
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Highly Cited
2003
Highly Cited
2003
CYP2C19 is an important human drug-metabolizing enzyme that metabolizes a number of clinically used drugs including the antiulcer… Expand
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Highly Cited
2003
Highly Cited
2003
The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mediate the expression of mammalian cytochrome p450… Expand
Highly Cited
2002
Highly Cited
2002
The CYP2C subfamily metabolizes many clinically important drugs. These genes respond to prototypical inducers such as… Expand
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Highly Cited
1998
Highly Cited
1998
The orphan receptor CAR-β (ref. 1) binds DNA as a heterodimer with the retinoid-X receptor and activates gene transcription in a… Expand