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anakinra

Known as: IL-1RN, rIL-1ra, ICIL-1RA 
A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1… 
National Institutes of Health

Related topics

Related topics

12 relations
0.67 ML anakinra 149 MG/ML Prefilled Syringe [Kineret]Anakinra:MCnc:Pt:Ser/Plas:QnCommunicable DiseasesDrug Allergy

Broader (1)

Interleukin 1 Receptor Antagonist Protein

Narrower (1)

Kineret

Papers overview

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Highly Cited
2006
Highly Cited
2006
Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury
Objective:Ischemia-reperfusion injury is known to cause organ failure, but the mechanisms of pathogenesis remain unclear… 
Highly Cited
2001
Highly Cited
2001
Gram-Positive and Gram-Negative Bacteria Do Not Trigger Monocytic Cytokine Production through Similar Intracellular Pathways
ABSTRACT Toll-like receptors (TLRs) are involved in human monocyte activation by lipopolysaccharide (LPS) and Staphylococcus… 
Highly Cited
2001
Highly Cited
2001
Production of IL‐1 receptor antagonist by hepatocytes is regulated as an acute‐phase protein in vivo
IL‐1 receptor antagonist (IL‐1Ra) is produced by isolated human hepatocytes with characteristics of an acute‐phase protein. There… 
Highly Cited
2000
Highly Cited
2000
Smoking and GCF levels of IL-1beta and IL-1ra in periodontal disease.
AIMS GCF levels of the cytokine IL-1beta and its receptor antagonist IL-1ra were analyzed with respect to smoking in patients… 
Highly Cited
1997
Highly Cited
1997
Circulating IL-1ra and IL-10 levels are increased but do not predict the development of acute respiratory distress syndrome in at-risk patients.
Although numerous cytokines, including interleukin (IL)-1, IL-8, and tumor necrosis factor, circulate in critically ill patients… 
Highly Cited
1996
Highly Cited
1996
Circulating serum levels of IL-1ra in patients with relapsing remitting multiple sclerosis are normal during remission phases but significantly increased either during exacerbations or in response to…
Interleukin (IL)-1 receptor antagonist (IL-1ra) is a naturally occurring inhibitor of IL-1 which binds to IL-1 receptors without… 
Highly Cited
1994
Highly Cited
1994
Grain dust-induced airflow obstruction and inflammation of the lower respiratory tract.
To investigate the relationship between the physiologic and biologic effects of grain dust inhalation, we exposed 15 nonsmoking… 
Highly Cited
1994
Highly Cited
1994
Elevated serum levels of interleukin-1 receptor antagonist in polymyositis/dermatomyositis. A biologic marker of disease activity with a possible role in the lack of acute-phase protein response.
OBJECTIVE To determine whether the lack of acute-phase protein (APP) response in numerous patients with polymyositis… 
Highly Cited
1993
Highly Cited
1993
Specific binding of interleukin 1 (IL-1) beta and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I.
Review
1993
Review
1993
Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus.
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