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anakinra

Known as: IL-1RN, rIL-1ra, ICIL-1RA 
A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1… 
National Institutes of Health

Related topics

Related topics

12 relations
0.67 ML anakinra 149 MG/ML Prefilled Syringe [Kineret]Anakinra:MCnc:Pt:Ser/Plas:QnCommunicable DiseasesDrug Allergy

Broader (1)

Interleukin 1 Receptor Antagonist Protein

Narrower (1)

Kineret

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study.
OBJECTIVE To evaluate the clinical response, safety, and tolerability of a single intraarticular injection of anakinra in… 
Highly Cited
2007
Highly Cited
2007
A pilot study of IL-1 inhibition by anakinra in acute gout
Monosodium urate crystals stimulate monocytes and macrophages to release IL-1β through the NALP3 component of the inflammasome… 
Highly Cited
2007
Highly Cited
2007
Relationship between adipocyte size and adipokine expression and secretion.
CONTEXT Adipocytes are known to release a variety of factors that may contribute to the proinflammatory state characteristic for… 
Review
2006
Review
2006
Orphanet Journal of Rare Diseases BioMed Central Review
  • 2006
  • Corpus ID: 271708
Highly Cited
2005
Highly Cited
2005
Rapid responses to anakinra in patients with refractory adult-onset Still's disease.
OBJECTIVE To assess the efficacy of anakinra treatment in patients with adult-onset Still's disease (AOSD) that is refractory to… 
Review
2004
Review
2004
Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra.
OBJECTIVE Mutations in the NALP3/CIAS1/PYPAF1 gene are associated with the autoinflammatory diseases Muckle-Wells syndrome (MWS… 
Highly Cited
2004
Highly Cited
2004
Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate.
OBJECTIVE To determine the potential for additive or synergistic effects of combination therapy with the selective anti-tumor… 
Review
2002
Review
2002
The role of cytokines in osteoarthritis pathophysiology.
Morphological changes observed in OA include cartilage erosion as well as a variable degree of synovial inflammation. Current… 
Highly Cited
2000
Highly Cited
2000
High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes
Lipopolysaccharide (LPS) is lethal to animals because it activates cytokine release, causing septic shock and tissue injury… 
Review
1996
Review
1996
Role of cytokines in rheumatoid arthritis.
Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that many proinflammatory cytokines such as TNF… 
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