anakinra

Known as: IL-1RN, rIL-1ra, ICIL-1RA 
A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
OBJECTIVES To assess the efficacy of the interleukin 1 receptor antagonist anakinra in systemic-onset juvenile idiopathic… (More)
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Highly Cited
2011
Highly Cited
2011
OBJECTIVE To examine the safety and efficacy of the interleukin-1 (IL-1) receptor antagonist anakinra as first-line therapy for… (More)
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Highly Cited
2010
Highly Cited
2010
Acute myocardial infarction (AMI) initiates an intense inflammatory response in which interleukin-1 (IL-1) plays a central role… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Experimental interleukin-1 receptor antagonist gene overexpression has shown that interleukin-1 receptor antagonist is… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Anakinra treatment has been reported to be effective in some patients with systemic-onset juvenile idiopathic… (More)
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Highly Cited
2007
Highly Cited
2007
CONTEXT Adipocytes are known to release a variety of factors that may contribute to the proinflammatory state characteristic for… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE To determine the potential for additive or synergistic effects of combination therapy with the selective anti-tumor… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE To assess the efficacy and safety of 100 mg daily anakinra (Kineret), a recombinant form of the naturally occurring… (More)
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Highly Cited
2000
Highly Cited
2000
Lipopolysaccharide (LPS) is lethal to animals because it activates cytokine release, causing septic shock and tissue injury… (More)
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Review
1996
Review
1996
Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that many proinflammatory cytokines such as TNF… (More)
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