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anagliptin

Known as: Pyrazolo(1,5-a)pyrimidine-6-carboxamide, N-(2-((2-((2S)-2-cyano-1-pyrrolidinyl)-2-oxoethyl)amino)-2-methylpropyl)-2-methyl- 
An orally available, potent, selective inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Compared to vildagliptin, anagliptin… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Pyrimidines

Narrower (1)

anagliptin hydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
MULTIPARTICULATE FLOATING DRUG DELIVERY SYSTEM OF ANAGLIPTIN: DESIGN AND OPTIMIZATION FOR ITS EFFICACY IN MANAGEMENT OF METABOLIC SYNDROME
Objective: The present research aims to design and optimize gastroretentive floating pellets of anagliptin (a dipeptidyl… 
2018
2018
Dipeptidyl peptidase 4 inhibitor anagliptin ameliorates hypercholesterolemia in hypercholesterolemic mice through inhibition of intestinal cholesterol transport
Recent data showed that dipeptidyl peptidase 4 (DPP‐4) inhibitors exert a lipid‐lowering effect in diabetes patients. However… 
2017
2017
DPP4 Inhibition Ameliorates Cardiac Function by Blocking the Cleavage of HMGB1 in Diabetic Mice After Myocardial Infarction.
High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, promotes angiogenesis and tissue repair, resulting in… 
2016
2016
Development and Validation of Five Simple UV-Spectrophotometry Methods for Estimation of Anagliptin in Bulk and in-house Tablets
Anagliptin is a Dipeptidyl peptidase-4 (DPP-4) inhibitor used in the treatment of diabetes. Five simple, specific, sensitive… 
2015
2015
The effect of anagliptin treatment on glucose metabolism and lipid metabolism, and oxidative stress in fasting and postprandial states using a test meal in Japanese men with type 2 diabetes
Keywords Anagliptin Test meal Adiponectin Remnant Renal function 8-OHdGIt has been generally recognized that postprandial hyper… 
2015
2015
Treatment with DPP-4I Anagliptin or α-GI Miglitol Reduces IGT Development and the Expression of CVD Risk Factors in OLETF Rats.
It has been reported that postprandial hyperglycemia from the pre-diabetic stage, especially from the impaired glucose tolerance… 
2013
2013
Pharmacokinetic disposition of anagliptin, a novel dipeptidyl peptidase-4 inhibitor, in rats and dogs
The pharmacokinetic disposition of anagliptin, an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor was… 
2013
2013
Dipeptidyl peptidase-4 inhibitor anagliptin ameliorates diabetes in mice with haploinsufficiency of glucokinase on a high-fat diet.
2013
2013
Inhibition of Postprandial Hyperglycemia by Either an Insulin-Dependent or -Independent Drug Reduces the Expression of Genes Related to Inflammation in Peripheral Leukocytes of OLETF Rats
Treatment with the dipeptidyl peptidase-4 inhibitor, anagliptin, or with the α-glucosidase inhibitor, miglitol, reduced the oral… 
2013
2013
The Relationship between Anagliptin Concentration Showing Over 80% Inhibition of Plasma Dipeptidyl Peptidase-4 Activity and its Protective Effect against Glucagon-like Peptide-1 Degradation
In dipeptidyl peptidase-4 (DPP-4) inhibitors, the inhibition of plasma DPP-4 activity by 80% is considered sufficient to have an… 
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