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amorpha-4,11-diene synthase

National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
The jasmonate-responsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L.
Plants of Artemisia annua produce artemisinin, a sesquiterpene lactone widely used in malaria treatment. Amorpha-4,11-diene… Expand
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2012
2012
Expression and Localization of Amorpha-4,11-diene Synthase in Artemisia annua L.
Artemisia annua L. is the only commercial source of the widely used antimalarial compound artemisinin. Biosynthesis of… Expand
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Highly Cited
2011
Highly Cited
2011
Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content
Artemisinin, an endoperoxide sesquiterpene lactone, is a novel antimalarial natural product isolated from Artemisia annua L… Expand
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2011
2011
Trichome-Specific Expression of Amorpha-4,11-Diene Synthase, a Key Enzyme of Artemisinin Biosynthesis in Artemisia annua L., as Reported by a Promoter-GUS Fusion
Artemisia annua L. produces small amounts of the sesquiterpenoid artemisinin, which is used for treatment of malaria. A worldwide… Expand
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Highly Cited
2009
Highly Cited
2009
Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesis.
Amorpha-4,11-diene synthase (ADS) of Artemisia annua catalyzes the conversion of farnesyl diphosphate into amorpha-4,11-diene… Expand
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2009
2009
The improvement of amorpha‐4,11‐diene production by a yeast‐conform variant
Aims:  To investigate the effect of the yeast‐conform variant of the Artemisia annua gene encoding for amorpha‐4,11‐diene… Expand
Highly Cited
2009
Highly Cited
2009
Salicylic acid activates artemisinin biosynthesis in Artemisia annua L.
This paper provides evidence that salicylic acid (SA) can activate artemisinin biosynthesis in Artemisia annua L. Exogenous… Expand
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2008
2008
Tissue specificity and developmental pattern of amorpha-4,11-diene synthase (ADS) proved by ADS promoter-driven GUS expression in the heterologous plant, Arabidopsis thaliana.
Amorpha-4,11-diene synthase (ADS) of Artemisia annua L. is a sesquiterpene cyclase that catalyzes the conversion of farnesyl… Expand
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Highly Cited
2006
Highly Cited
2006
Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis.
Cyclization of farnesyl diphosphate into amorpha-4,11-diene by amorpha-4,11-diene synthase (ADS) initiates biosynthesis of… Expand
Highly Cited
2004
Highly Cited
2004
A single-vial analytical and quantitative gas chromatography-mass spectrometry assay for terpene synthases.
A quantitative assay for the analysis of sesquiterpene synthases, wherein each reaction mixture is formulated in glass gas… Expand
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