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amdoxovir

Known as: 2,6-diaminopurine dioxolane, 4-(2,6-diamino-9H-purin-9-yl)-1,3,-dioxolane-2-methanol 
A nucleoside reverse transcriptase inhibitor prodrug analog of guanosine.
National Institutes of Health

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2 relations

Broader (2)

DioxolanesPurine Nucleosides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals
Background Amdoxovir acts synergistically with zidovudine in vitro and the combination prevents or delays the selection of… 
2007
2007
The use of β-D-2,6-diaminopurine dioxolane with or without mycophenolate mofetil in drug-resistant HIV infection
Objective:We evaluated the safety, tolerability and antiretroviral activity of β-D-2,6-diaminopurine dioxolane (DAPD; amdoxovir… 
2005
2005
Short-term safety and pharmacodynamics of amdoxovir in HIV-infected patients
Objectives:To evaluate the pharmacodynamics and safety of escalating doses of amdoxovir (DAPD) monotherapy administered to… 
Review
2005
Review
2005
Amdoxovir versus Placebo with Enfuvirtide plus Optimized Background Therapy for HIV-1-Infected Subjects Failing Current Therapy (Aactg A5118)
Background Amdoxovir (2,6-diaminopurine dioxolane; DAPD) is a nucleoside reverse transcriptase inhibitor (NRTI) of human… 
Review
2005
Review
2005
New targets and new drugs in the treatment of HIV.
2003
2003
Dioxolane Guanosine 5′-Triphosphate, an Alternative Substrate Inhibitor of Wild-type and Mutant HIV-1 Reverse Transcriptase
The frequency of human immunodeficiency virus, type 1 (HIV-1) mutations in response to antiviral therapy and resulting drug… 
Highly Cited
2002
Highly Cited
2002
Dioxolane Guanosine, the Active Form of the Prodrug Diaminopurine Dioxolane, Is a Potent Inhibitor of Drug‐Resistant HIV‐1 Isolates From Patients for Whom Standard Nucleoside Therapy Fails
Summary: Amdoxovir ([‐]‐&bgr;‐D‐2,6‐diaminopurine dioxolane [DAPD]) is a nucleoside reverse transcriptase inhibitor (NRTI) with… 
Highly Cited
2002
Highly Cited
2002
ATP-Dependent Removal of Nucleoside Reverse Transcriptase Inhibitors by Human Immunodeficiency Virus Type 1 Reverse Transcriptase
ABSTRACT Removal of nucleoside chain terminator inhibitors mediated by human immunodeficiency virus (HIV) reverse transcriptase… 
2002
2002
Molecular Mechanism of DAPD/DXG against Zidovudine- and Lamivudine- Drug Resistant Mutants: A Molecular Modelling Approach
In order to understand molecular mechanism of antiviral drug resistance of HIV-1 reverse transcriptase (RT) as well as potent… 
1999
1999
Anti-HIV-1 activities of 1,3-dioxolane guanine and 2,6-diaminopurine dioxolane.
DXG and its prodrug DAPD have been demonstrated to be effective inhibitors of HIV-1 in various cells. The EC50s for DXG were 0… 
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