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amdoxovir

Known as: 2,6-diaminopurine dioxolane, 4-(2,6-diamino-9H-purin-9-yl)-1,3,-dioxolane-2-methanol 
A nucleoside reverse transcriptase inhibitor prodrug analog of guanosine.
National Institutes of Health

Papers overview

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2010
2010
Nucleoside reverse transcriptase inhibitors (NRTI) require intracellular phosphorylation, which involves multiple enzymatic steps… Expand
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Highly Cited
2007
Highly Cited
2007
Three classes of antiretroviral agents are usually available for the treatment of HIV infection: nucleoside reverse transcriptase… Expand
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Highly Cited
2005
Highly Cited
2005
There are now exactly 20 anti-HIV drugs licenced (approved) for clinical use, and > 30 anti-HIV compounds under (pre)clinical… Expand
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2005
2005
Objectives:To evaluate the pharmacodynamics and safety of escalating doses of amdoxovir (DAPD) monotherapy administered to… Expand
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2004
2004
ABSTRACT Amdoxovir [(−)-β-d-2,6-diaminopurine dioxolane (DAPD)] is a nucleoside analogue reverse transcriptase inhibitor of human… Expand
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Review
2004
Review
2004
Several new nucleoside analogs are currently in development for the treatment of HIV-1 infections. Alovudine, amdoxovir… Expand
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Review
2003
Review
2003
  • Roy M. Gulick
  • Clinical microbiology and infection : the…
  • 2003
  • Corpus ID: 9246203
Despite the availability of 16 antiretroviral drugs approved for the treatment of HIV infection, current combination regimens… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutations K65R and M184V result in… Expand
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2002
2002
Summary: Amdoxovir ([‐]‐&bgr;‐D‐2,6‐diaminopurine dioxolane [DAPD]) is a nucleoside reverse transcriptase inhibitor (NRTI) with… Expand
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2001
2001
There are a number of virus-specific processes within the virus replicative cycle or virus-infected cell that have proven to be… Expand
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