amdoxovir

Known as: 2,6-diaminopurine dioxolane, 4-(2,6-diamino-9H-purin-9-yl)-1,3,-dioxolane-2-methanol 
A nucleoside reverse transcriptase inhibitor prodrug analog of guanosine.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2016
024619962016

Papers overview

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2007
2007
Isatin (1H-indol-2,3-dione) is an endogenous compound found in many tissues and fluids. Isatin and its derivatives exert… (More)
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2005
2005
OBJECTIVES To evaluate the pharmacodynamics and safety of escalating doses of amdoxovir (DAPD) monotherapy administered to… (More)
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2004
2004
Amdoxovir [(-)-beta-D-2,6-diaminopurine dioxolane, DAPD], the prodrug of dioxolane guanosine (DXG), is currently in Phase I/II… (More)
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2002
2002
PURPOSE To investigate the activity of a novel dioxolane L-nucleoside analog, troxacitabine (L-(-)-OddC, BCH-4556), in patients… (More)
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2002
2002
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutations K65R and M184V result in changes in… (More)
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2001
2001
Prolonged treatment of chronic hepatitis B virus (HBV) infection with lamivudine ([-]-beta-L-2',3'-dideoxy-3' thiacytidine) or… (More)
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2001
2001
(-)-beta-D-2,6-Diaminopurine dioxolane (DAPD), is a nucleoside reverse transcriptase (RT) inhibitor with activity against human… (More)
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2000
2000
PHILLIP A. FURMAN,* JERRY JEFFREY, LAURA L. KIEFER, JOY Y. FENG, KAREN S. ANDERSON, KATYNA BORROTO-ESODA, EDGAR HILL, WILLIAM C… (More)
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1999
1999
DXG and its prodrug DAPD have been demonstrated to be effective inhibitors of HIV-1 in various cells. The EC50s for DXG were 0… (More)
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1996
1996
(-)-beta-D-2-Aminopurine dioxolane (APD) and (-)-beta-D-2-amino-6-chloropurine dioxolane (ACPD) are recently synthesized… (More)
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