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Hydropyran rings are a common structural motif in reduced polyketides. Information on their biosynthetic formation and… Expand ABSTRACT We have shown that the plant pathogen Alternaria brassicicola exhibited very high susceptibility to ambruticin VS4 and… Expand ABSTRACT The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of… Expand Ambruticins and jerangolids are structurally related antifungal polyketides produced by Sorangium cellulosum strains. Comparative… Expand ABSTRACT Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two… Expand A convergent total synthesis of the novel antifungal agent ambruticin S (1) has been completed from the assembly of intermediates… Expand The myxobacterial fungicide, ambruticin, kills the yeast, Hansenula anomala, with high efficacy (MIC 0.05 microg/ml), but only… Expand Oral administration of ambruticin (W7783) (by gavage) was lifesaving in mice infected intranasally with arthrospores of… Expand Ambruticin is a cyclopropyl-pyran acid, representing a new class of antibiotics. It has a relatively broad antifungal spectrum in… Expand Ambruticin represents a new class of antibiotics isolated from a strain of Polyangium cellulosum var, fulvum, a bacterium… Expand