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ambruticin

Known as: 5,6-dihydroxypolyangioic acid 
A natural polyketide isolated from the myxobacteria Sorangium cellulosum with antifungal activity. Ambruticin interferes with the osmoregulatory… Expand
National Institutes of Health

Papers overview

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2014
2014
Hydropyran rings are a common structural motif in reduced polyketides. Information on their biosynthetic formation and… Expand
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2008
2008
ABSTRACT We have shown that the plant pathogen Alternaria brassicicola exhibited very high susceptibility to ambruticin VS4 and… Expand
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2007
2007
ABSTRACT The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of… Expand
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Highly Cited
2006
Highly Cited
2006
Ambruticins and jerangolids are structurally related antifungal polyketides produced by Sorangium cellulosum strains. Comparative… Expand
2006
2006
ABSTRACT Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two… Expand
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2001
2001
A convergent total synthesis of the novel antifungal agent ambruticin S (1) has been completed from the assembly of intermediates… Expand
2000
2000
The myxobacterial fungicide, ambruticin, kills the yeast, Hansenula anomala, with high efficacy (MIC 0.05 microg/ml), but only… Expand
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1978
1978
Oral administration of ambruticin (W7783) (by gavage) was lifesaving in mice infected intranasally with arthrospores of… Expand
1978
1978
  • S. Ringel
  • Antimicrobial Agents and Chemotherapy
  • 1978
  • Corpus ID: 5451537
Ambruticin is a cyclopropyl-pyran acid, representing a new class of antibiotics. It has a relatively broad antifungal spectrum in… Expand
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Highly Cited
1977
Highly Cited
1977
Ambruticin represents a new class of antibiotics isolated from a strain of Polyangium cellulosum var, fulvum, a bacterium… Expand
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