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ambruticin

Known as: 5,6-dihydroxypolyangioic acid 
A natural polyketide isolated from the myxobacteria Sorangium cellulosum with antifungal activity. Ambruticin interferes with the osmoregulatory… 
National Institutes of Health

Papers overview

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2014
2014
Hydropyran rings are a common structural motif in reduced polyketides. Information on their biosynthetic formation and… 
2008
2008
ABSTRACT We have shown that the plant pathogen Alternaria brassicicola exhibited very high susceptibility to ambruticin VS4 and… 
2007
2007
ABSTRACT The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of… 
2006
2006
ABSTRACT Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two… 
2001
2001
A convergent total synthesis of the novel antifungal agent ambruticin S (1) has been completed from the assembly of intermediates… 
2000
2000
The myxobacterial fungicide, ambruticin, kills the yeast, Hansenula anomala, with high efficacy (MIC 0.05 microg/ml), but only… 
Highly Cited
1996
Highly Cited
1996
An antifungal activity was detected in the culture broth of the myxobacterium, Sorangium cellulosum strain So ce 307. The… 
1978
1978
Oral administration of ambruticin (W7783) (by gavage) was lifesaving in mice infected intranasally with arthrospores of… 
Highly Cited
1977
Highly Cited
1977
Ambruticin represents a new class of antibiotics isolated from a strain of Polyangium cellulosum var, fulvum, a bacterium…