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ambruticin

Known as: 5,6-dihydroxypolyangioic acid 
A natural polyketide isolated from the myxobacteria Sorangium cellulosum with antifungal activity. Ambruticin interferes with the osmoregulatory… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Pyrans

Narrower (1)

W7783

Papers overview

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2008
2008
The Group III Two-Component Histidine Kinase of Filamentous Fungi Is Involved in the Fungicidal Activity of the Bacterial Polyketide Ambruticin
ABSTRACT We have shown that the plant pathogen Alternaria brassicicola exhibited very high susceptibility to ambruticin VS4 and… 
2006
2006
Investigating Carboxylic Acid Analogues of Ambruticin through Semi‐Synthesis
Systemic fungal infections have increased significantly in recent years, principally in immunocompromised patients. This is… 
2002
2002
Total Synthesis of (+)-Ambruticin S.
A convergent total synthesis of the novel antifungal agent ambruticin S (1) has been completed from the assembly of intermediates… 
2002
2002
Total Synthesis of Ambruticin
2000
2000
On the mechanism of action of the myxobacterial fungicide ambruticin.
The myxobacterial fungicide, ambruticin, kills the yeast, Hansenula anomala, with high efficacy (MIC 0.05 microg/ml), but only… 
1979
1979
Antifungal agents. 4. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Ester and amide analogues of ambruticin.
A series of ester and amide analogues of ambruticin (1) was prepared. The analogues were tested against Histoplasma capsulatum… 
1978
1978
Therapeutic properties of oral ambruticin (W7783) in experimental pulmonary coccidioidomycosis of mice.
Oral administration of ambruticin (W7783) (by gavage) was lifesaving in mice infected intranasally with arthrospores of… 
1978
1978
In Vitro and In Vivo Studies of Ambruticin (W7783): New Class of Antifungal Antibiotics
Ambruticin is a cyclopropyl-pyran acid, representing a new class of antibiotics. It has a relatively broad antifungal spectrum in… 
1978
1978
In Vivo Studies with Ambruticin in Murine Histoplasmosis
Ambruticin (W7783) was evaluated in vivo in mice subacutely or nonlethally infected with Histoplasma capsulatum. Results were… 
1978
1978
In Vitro Studies with Ambruticin, a New Antifungal Antibiotic
The in vitro antifungal inhibitory activities of ambruticin and of various antifungal drugs of choice against 190 fungal… 
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