On the mechanism of action of the myxobacterial fungicide ambruticin.

@article{Knauth2000OnTM,
  title={On the mechanism of action of the myxobacterial fungicide ambruticin.},
  author={Paul L Knauth and H. Graf von Reichenbach},
  journal={The Journal of antibiotics},
  year={2000},
  volume={53 10},
  pages={1182-90}
}
The myxobacterial fungicide, ambruticin, kills the yeast, Hansenula anomala, with high efficacy (MIC 0.05 microg/ml), but only when the cells are growing. The earliest effect, observed almost immediately after the addition of the antibiotic, is a transient but substantial increase of intracellular glycerol, followed by an accumulation of triacylglycerols and free fatty acids. At about the time when free fatty acids accumulate, the cells become leaky to low molecular weight compounds. We assume… CONTINUE READING