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alglucerase

Known as: alglucerase [Chemical/Ingredient] 
National Institutes of Health

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6 relations
Drug AllergyEnzymatic Activity [MoA]GLUCOSYLCERAMIDASELiver diseases

Papers overview

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Highly Cited
2009
Highly Cited
2009
Dose-response relationships for enzyme replacement therapy with imiglucerase/alglucerase in patients with Gaucher disease type 1
Purpose: To determine whether enzyme therapy with imiglucerase/alglucerase demonstrates dose-response relationships with doses… 
1997
1997
8 Enzyme replacement therapy for Gaucher's disease
Highly Cited
1997
Highly Cited
1997
Plasma chitotriosidase activity in Gaucher disease patients who have been treated either by bone marrow transplantation or by enzyme replacement therapy with alglucerase
A marked elevation in plasma chitotriosidase (chitinase) activity has recently been observed in patients with Gaucher disease… 
1996
1996
Pulmonary Hypertension Developing after Alglucerase Therapy in Two Patients with Type 1 Gaucher Disease Complicated by the Hepatopulmonary Syndrome
Gaucher disease is an autosomal-recessive disorder that is caused by a deficiency of the enzyme glucocerebrosidase and results in… 
Highly Cited
1995
Highly Cited
1995
The clinical course of treated and untreated Gaucher disease. A study of 45 patients.
One hundred nineteen patients with Gaucher disease were examined in the past 13 years. Of these 45 were examined 3 or more times… 
Highly Cited
1994
Highly Cited
1994
Low-dose enzyme replacement therapy for Gaucher's disease: effects of age, sex, genotype, and clinical features on response to treatment.
Highly Cited
1994
Highly Cited
1994
Enzyme replacement treatment in type 1 and type 3 Gaucher's disease
Highly Cited
1993
Highly Cited
1993
Enzyme therapy in Gaucher disease type 1: dosage efficacy and adverse effects in 33 patients treated for 6 to 24 months.
Gaucher disease is the most frequent lysosomal storage disease and the most prevalent genetic disease among the Ashkenazi Jews (q… 
Highly Cited
1993
Highly Cited
1993
Binding, internalization, and degradation of mannose-terminated glucocerebrosidase by macrophages.
Mannose-terminated glucocerebrosidase (alglucerase; Ceredase) was designed for enzyme replacement therapy in Gaucher disease to… 
Highly Cited
1992
Highly Cited
1992
A less costly regimen of alglucerase to treat Gaucher's disease.
BACKGROUND Alglucerase (Ceredase) provides effective enzyme-replacement treatment for patients with Gaucher's disease, but at the… 
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