alglucerase

Purpose: To determine whether enzyme therapy with imiglucerase/alglucerase demonstrates dose-response relationships with doses… Expand

Alglucerase, a macrophage-targeted enzyme replacement therapy for Gaucher disease, has been successfully used for several years… Expand

A marked elevation in plasma chitotriosidase (chitinase) activity has recently been observed in patients with Gaucher disease… Expand

OBJECTIVES The incidence and severity of growth retardation in children with type 1 Gaucher disease and the response to enzyme… Expand

Gaucher disease is an autosomal-recessive disorder that is caused by a deficiency of the enzyme glucocerebrosidase and results in… Expand

Previous studies have shown that enzyme supplementation therapy with alglucerase for type 1 Gaucher's disease is effective at… Expand

One hundred nineteen patients with Gaucher disease were examined in the past 13 years. Of these 45 were examined 3 or more times… Expand

Gaucher disease is the most frequent lysosomal storage disease and the most prevalent genetic disease among the Ashkenazi Jews (q… Expand

Mannose-terminated glucocerebrosidase (alglucerase; Ceredase) was designed for enzyme replacement therapy in Gaucher disease to… Expand

BACKGROUND Alglucerase (Ceredase) provides effective enzyme-replacement treatment for patients with Gaucher's disease, but at the… Expand