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alglucerase

Known as: alglucerase [Chemical/Ingredient] 
National Institutes of Health

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6 relations
Drug AllergyEnzymatic Activity [MoA]GLUCOSYLCERAMIDASELiver diseases

Papers overview

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2017
2017
Transformation in pretreatment manifestations of Gaucher disease type 1 during two decades of alglucerase/imiglucerase enzyme replacement therapy in the International Collaborative Gaucher Group…
This study tests the hypothesis that the prevalence of severe clinical manifestations in Gaucher disease type 1 (GD1) patients at… 
Highly Cited
2009
Highly Cited
2009
Dose-response relationships for enzyme replacement therapy with imiglucerase/alglucerase in patients with Gaucher disease type 1
Purpose: To determine whether enzyme therapy with imiglucerase/alglucerase demonstrates dose-response relationships with doses… 
Highly Cited
1999
Highly Cited
1999
Immunosurveillance of alglucerase enzyme therapy for Gaucher patients: induction of humoral tolerance in seroconverted patients after repeat administration.
Alglucerase, a macrophage-targeted enzyme replacement therapy for Gaucher disease, has been successfully used for several years… 
1997
1997
8 Enzyme replacement therapy for Gaucher's disease
Highly Cited
1997
Highly Cited
1997
Differential effects of enzyme supplementation therapy on manifestations of type 1 Gaucher disease.
Highly Cited
1996
Highly Cited
1996
Therapeutic delivery of proteins to macrophages: implications for treatment of Gaucher's disease
Highly Cited
1994
Highly Cited
1994
Low-dose enzyme replacement therapy for Gaucher's disease: effects of age, sex, genotype, and clinical features on response to treatment.
Highly Cited
1994
Highly Cited
1994
Enzyme replacement treatment in type 1 and type 3 Gaucher's disease
Highly Cited
1993
Highly Cited
1993
Enzyme therapy in Gaucher disease type 1: dosage efficacy and adverse effects in 33 patients treated for 6 to 24 months.
Gaucher disease is the most frequent lysosomal storage disease and the most prevalent genetic disease among the Ashkenazi Jews (q… 
Highly Cited
1992
Highly Cited
1992
A less costly regimen of alglucerase to treat Gaucher's disease.
BACKGROUND Alglucerase (Ceredase) provides effective enzyme-replacement treatment for patients with Gaucher's disease, but at the… 
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