afuresertib

An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Afuresertib… (More)

Topic mentions per year

Topic mentions per year

2014-2016
012320142016

Papers overview

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2017
2017
BACKGROUND Langerhans cell histiocytosis (LCH) is a clonal neoplasm characterized by widely varied clinical presentations… (More)
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2017
2017
Malignant pleural mesothelioma (MPM), an asbestos-related occupational disease, is an aggressive and incurable tumor of the… (More)
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Review
2016
Review
2016
Multiple myeloma (MM) is a disease that affects plasma cells and can lead to devastating clinical features such as anemia, lytic… (More)
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2014
2014
The PI3K/AKT pathway is constitutively active in hematologic malignancies, providing proliferative and antiapoptotic signals and… (More)
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2014
2014
To identify the maximum tolerated dose (MTD) and recommended Phase II dose of MEK/AKT inhibitor combination of trametinib and… (More)
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