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acetyldinaline

Known as: 4-acetylamino-N-(2'-aminophenyl)benzamide, Tacedinaline, N-acetyl Dinaline 
An orally bioavailable substituted benzamide derivative with potential antineoplastic activity. Tacedinaline inhibits histone deacetylation, which… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (2)

CI 994PD 123654

Broader (1)

Phenylenediamines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Preclinical toxicity of a new oral anticancer drug, CI-994 (Acetyldinaline), in rats and dogs
CI-994 (acetyldinaline) is an orally active anticancer drug currently in Phase 1 clinical trials. To assess int preclinical… 
2004
2004
Preclinical pharmacokinetic, antitumor and toxicity studies with CL-994 (N-acetyldinaline)
CI-994, a substituted benzamide derivative, is a compound that showed solid tumor selectivity for a variety of solid tumor models… 
2004
2004
In vitro and in vivo effects of acetyldinaline on murine megakaryocytopoiesis
PurposeAcetyldinaline (CI-994) has shown preclinical efficacy in vitro and in vivo against solid tumor and leukemia cell lines… 
2000
2000
Pharmacokinetics and cerebrospinal fluid penetration of CI-994 (N-acetyldinaline) in the nonhuman primate.
CI-994 is a substituted benzamide derivative that has demonstrated significant antitumor activity in vitro and in vivo against a… 
1999
1999
Immunotoxicity of the anticancer drug CI-994 in rats: effects on lymphoid tissue
Abstract CI-994 (acetyldinaline) is an investigative oral anticancer drug currently in clinical trials. To characterize the… 
1997
1997
Preclinical pharmacokinetic, antitumor and toxicity studies with CI-994 (correction of CL-994) (N-acetyldinaline).
CI-994, a substituted benzamide derivative, is a compound that showed solid tumor selectivity for a variety of solid tumor models… 
1995
1995
Role of a small molecular weight phosphoprotein in the mechanism of action of CI‐994 (N‐acetyldinaline)
The mechanism of action of the novel anti‐cancer compound CI‐994 was studied in C26 murine colon tumor and HCT‐8 human colon… 
1993
1993
Efficacy of acetyldinaline for treatment of minimal residual disease (MRD): preclinical studies in the BNML rat model for human acute myelocytic leukemia.
The efficacy of acetyldinaline [4-acetylamino-N-(2'-aminophenyl)-benzamide] for eradication of minimal residual disease (MRD… 
1993
1993
In vivo development of an acetyldinaline resistant subline of the BN rat acute myelocytic leukemia (BNML).
The cytostatic drug acetyldinaline [ACD, CI-994, 4-acetylamine-N-(2-aminophenyl)-benzamide] shows an extreme antileukemic effect… 
1988
1988
Dinaline: a new oral drug against leukemia? Preclinical studies in a relevant rat model for human acute myelocytic leukemia (BNML).
The efficacy and toxicity of Dinaline (GOE 1734; PD 104 208; NSC 328786; 4-amino-N-(2'-aminophenyl)benzamide) was evaluated in… 
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