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Zinostatin

Known as: NCS, Holoneocarzinostatin, Neocarzinostatin 
An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces… 
National Institutes of Health

Related topics

Related topics

17 relations

Broader (4)

Antibiotics, AntineoplasticCytotoxinNucleic Acid Synthesis InhibitorsPeptides
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Narrower (5)

NFO protocolNHO protocolaponeocarzinostatinneocarzinostatin chromophore

Papers overview

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Highly Cited
2005
Highly Cited
2005
Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.
Nonhomologous end-joining (NHEJ) DNA factors maintain genomic stability through their DNA double-strand break (DSB) repair and… 
Highly Cited
2003
Highly Cited
2003
Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response*
Cdc25C and p53 have been reported to be physiological targets of checkpoint kinase 2 (Chk2). Surprisingly, although Chk2 purified… 
Highly Cited
2001
Highly Cited
2001
Heat-induced unfolding of neocarzinostatin, a small all-beta protein investigated by small-angle X-ray scattering.
Neocarzinostatin is an all-beta protein, 113 amino acid residues long, with an immunoglobulin-like fold. Its thermal unfolding… 
Highly Cited
1991
Highly Cited
1991
Distribution of GAP-43 mRNA in the brain stem of adult rats as evidenced by in situ hybridization: localization within monoaminergic neurons
Using in situ hybridization, we examined the distribution of the mRNA encoding for the growth-associated protein GAP-43 in the… 
Highly Cited
1989
Highly Cited
1989
A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity.
C-1027, a new macromolecular antitumor antibiotic produced by Streptomyces globisporus C-1027, showed extremely potent… 
Highly Cited
1979
Highly Cited
1979
Neocarzinostatin: spectral characterization and separation of a non-protein chromophore.
Highly Cited
1976
Highly Cited
1976
The cause of G2-arrest in Chinese hamster ovary cells treated with anticancer drugs.
The nature of G2-arrest was studied in Chinese hamster ovary cells after exposure to 4'-demethyl-epipodophyllotoxin 9-)4,6-0-2… 
Highly Cited
1974
Highly Cited
1974
DNA strand scission by the antitumor protein neocarzinostatin.
Highly Cited
1972
Highly Cited
1972
Primary Structure of Neocarzinostatin, an Antitumor Protein
The antitumor protein neocarzinostatin is an acidic single-chain molecule, cross-linked by two disulfide bridges, and consists of… 
Highly Cited
1966
Highly Cited
1966
Mode of action of neocarzinostatin: inhibition of DNA synthesis and degradation of DNA in Sarcina lutea.
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