Zactima
National Institutes of Health
Papers overview
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Medullary thyroid cancer (MTC), a neuroendocrine tumor arising from the parafollicular C cells of the thyroid gland, is rare and…
Traditionally available treatments, like cytotoxic chemotherapy and external-beam radiation therapy, are limited and essentially…
Vandetanib (ZD6474, Zactima™) is a novel, orally available inhibitor of different intracellular signaling pathways involved in…
We investigated the effects of vandetanib, an inhibitor of vascular endothelial growth factor receptor 2 (VEGFR‐2) and epidermal…
High‐risk cases of neuroblastoma have poor survival rates, and novel therapies are needed. Vandetanib (ZD6474, Zactima) is an…
Opinion statementAdvanced bladder/urothelial cancer remains an incurable terminal disease, and accounts for 3% of the cancer…
The prognosis of patients diagnosed with malignant glioma (MG) remains poor. However, recent advances in neuro-oncology allowing…
To date, clinical studies combining the new generation of targeted therapies and chemotherapy have had mixed results. Preclinical…