ZD 6474

Known as: AZD6474, ZD-6474, ZD6474 
An orally bioavailable 4-anilinoquinazoline. ZD-6474 selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor… (More)
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Vandetanib is a novel, orally available inhibitor of different intracellular signaling pathways involved in tumor growth… (More)
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Review
2008
Review
2008
The mechanisms involved in the epithelial to mesenchymal transition (EMT) are integrated in concert with master developmental and… (More)
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Review
2007
Review
2007
Glioma has been considered resistant to chemotherapy and radiation. Recently, concomitant and adjuvant chemoradiotherapy with… (More)
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Highly Cited
2006
Highly Cited
2006
INTRODUCTION ZD6474 (vandetanib) is an orally available inhibitor of vascular endothelial growth factor receptor, epidermal… (More)
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Review
2006
Review
2006
Angiogenesis plays a central role in the process of tumor growth and metastatic dissemination. The vascular endothelial growth… (More)
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Highly Cited
2005
Highly Cited
2005
To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND ZD6474 selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor and epidermal… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE In the brain, tumors may grow without inducing angiogenesis, via co-option of the dense pre-existent capillary bed. The… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE The epidermal growth factor receptor (EGFR) autocrine signaling pathway is involved in cancer development and progression… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE Vascular endothelial growth factor (VEGF) is a major mitogen for endothelial cells and enhances vascular permeability… (More)
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