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ZD 6474

Known as: AZD6474, ZD-6474, ZD6474 
An orally bioavailable 4-anilinoquinazoline. ZD-6474 selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor… Expand
National Institutes of Health

Papers overview

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Review
2008
Review
2008
The mechanisms involved in the epithelial to mesenchymal transition (EMT) are integrated in concert with master developmental and… Expand
Review
2007
Review
2007
Glioma has been considered resistant to chemotherapy and radiation. Recently, concomitant and adjuvant chemoradiotherapy with… Expand
Review
2006
Review
2006
Angiogenesis plays a central role in the process of tumor growth and metastatic dissemination. The vascular endothelial growth… Expand
Highly Cited
2005
Highly Cited
2005
BACKGROUND ZD6474 selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor and epidermal… Expand
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Highly Cited
2005
Highly Cited
2005
To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the… Expand
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Highly Cited
2004
Highly Cited
2004
Purpose: The epidermal growth factor receptor (EGFR) autocrine signaling pathway is involved in cancer development and… Expand
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Highly Cited
2003
Highly Cited
2003
PURPOSE Vascular endothelial growth factor (VEGF) is a major mitogen for endothelial cells and enhances vascular permeability… Expand
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Highly Cited
2002
Highly Cited
2002
ZD6474 [N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine]is a potent, p.o. active, low… Expand
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Highly Cited
2002
Highly Cited
2002
RET/papillary thyroid carcinoma (PTC) oncogenes, generated by recombination of the tyrosine kinase-encoding domain of RET with… Expand
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Highly Cited
1988
Highly Cited
1988
The activity of thymulin (a thymic hormone) is dependent on the presence of zinc in the molecule. We assayed serum thymulin… Expand
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