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ZD 6474

Known as: AZD6474, ZD-6474, ZD6474 
An orally bioavailable 4-anilinoquinazoline. ZD-6474 selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor… Expand
National Institutes of Health

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Review
2008
Review
2008
The mechanisms involved in the epithelial to mesenchymal transition (EMT) are integrated in concert with master developmental and… Expand
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Review
2007
Review
2007
Glioma has been considered resistant to chemotherapy and radiation. Recently, concomitant and adjuvant chemoradiotherapy with… Expand
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Review
2006
Review
2006
Angiogenesis plays a central role in the process of tumor growth and metastatic dissemination. The vascular endothelial growth… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND ZD6474 selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor and epidermal… Expand
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Highly Cited
2005
Highly Cited
2005
Purpose: To determine the efficacy and safety of ZD6474, an orally available inhibitor of vascular endothelial growth factor… Expand
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Highly Cited
2004
Highly Cited
2004
Purpose: The epidermal growth factor receptor (EGFR) autocrine signaling pathway is involved in cancer development and… Expand
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Highly Cited
2003
Highly Cited
2003
PURPOSE Vascular endothelial growth factor (VEGF) is a major mitogen for endothelial cells and enhances vascular permeability… Expand
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Highly Cited
2002
Highly Cited
2002
ZD6474 [N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine]is a potent, p.o. active, low… Expand
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Highly Cited
2002
Highly Cited
2002
RET/papillary thyroid carcinoma (PTC) oncogenes, generated by recombination of the tyrosine kinase-encoding domain of RET with… Expand
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Highly Cited
1988
Highly Cited
1988
The activity of thymulin (a thymic hormone) is dependent on the presence of zinc in the molecule. We assayed serum thymulin… Expand
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