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ZSTK474
Known as:
PI3K Inhibitor ZSTK474
, Phosphatidylinositol 3-kinase Inhibitor ZSTK474
An orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity…
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National Institutes of Health
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Related topics
Related topics
2 relations
NCIt Antineoplastic Agent Terminology
Broader (1)
Triazines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Hydroxysafflor yellow a protects brain microvascular endothelial cells against oxygen glucose deprivation/reoxygenation injury: Involvement of inhibiting autophagy via class I PI3K/Akt/mTOR signaling…
Guang Yang
,
Ning Wang
,
S. Seto
,
D. Chang
,
H. Liang
Brain Research Bulletin
2018
Corpus ID: 21753910
2016
2016
WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways.
Jin Meng
,
Xu-tao Zhang
,
+8 authors
Tao Zhang
Cellular Signalling
2016
Corpus ID: 36144839
Review
2012
Review
2012
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Dexin Kong
,
T. Yamori
Bioorganic & Medicinal Chemistry
2012
Corpus ID: 24063021
Highly Cited
2011
Highly Cited
2011
Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H…
G. Rewcastle
,
S. Gamage
,
+13 authors
P. Shepherd
Journal of Medicinal Chemistry
2011
Corpus ID: 22678361
A structure-activity relationship (SAR) study of the pan class I PI 3-kinase inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl…
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Highly Cited
2010
Highly Cited
2010
Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39.
Dexin Kong
,
S. Dan
,
K. Yamazaki
,
T. Yamori
European Journal of Cancer
2010
Corpus ID: 25049602
Review
2010
Review
2010
ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system
De-Xin Kong
,
T. Yamori
Acta Pharmacologica Sinica
2010
Corpus ID: 7927395
AbstractJFCR39 is an informatic anticancer drug discovery system that utilizes a panel of 39 human cancer cells coupled with a…
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Highly Cited
2009
Highly Cited
2009
Effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor, on DNA-dependent protein kinase.
Dexin Kong
,
S. Yaguchi
,
T. Yamori
Biological and Pharmaceutical Bulletin
2009
Corpus ID: 29449925
Phosphatidylinositol 3-kinase (PI3K) has been implicated in a variety of diseases including cancer. A number of PI3K inhibitors…
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Review
2009
Review
2009
Advances in development of phosphatidylinositol 3-kinase inhibitors.
Dexin Kong
,
T. Yamori
Current Medicinal Chemistry
2009
Corpus ID: 31139115
Phosphatidylinositol 3-kinases (PI3Ks) are a class of lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate…
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Highly Cited
2007
Highly Cited
2007
ZSTK474 is an ATP‐competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms
Dexin Kong
,
T. Yamori
Cancer Science
2007
Corpus ID: 25569359
Class I phosphatidylinositol 3 kinases (PI3K) phosphorylate phosphatidylinositol 4,5‐bisphosphate to generate…
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Highly Cited
2006
Highly Cited
2006
Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.
S. Yaguchi
,
Y. Fukui
,
+6 authors
T. Yamori
Journal of the National Cancer Institute
2006
Corpus ID: 1065231
BACKGROUND We previously synthesized a novel s-triazine derivative, ZSTK474 [2-(2-difluoromethylbenzimidazol-1-yl)-4,6…
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