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The aim of this study was to find out polymeric compounds that can inhibit the interaction between YM466, a novel anticoagulant… Expand SummaryThe pharmacokinetics of YM466, a selective inhibitor for factor Xa, was investigated after single intravenous and oral… Expand SummaryYM466, a novel factor Xa inhibitor, is a hydrophilic compound with a carboxylic acid moiety. Previous studies in rats have… Expand A simple, quantitative, and reproducible model of lower limb ischemia was developed. Vascular injury was induced by ferric… Expand Thrombosis and neointima formation limit the efficacy of coronary angioplasty. Factor Xa inhibitors and GPIIb/IIIa antagonists… Expand YM466 is a novel factor Xa inhibitor for the treatment of thrombosis. The absorption, distribution, metabolism and excretion of… Expand A sensitive and selective method for the determination of YM466, a novel Factor Xa inhibitor, in rat plasma was developed and… Expand Abstract Various solubilizing agents for YM466, a new Factor Xa inhibitor, were investigated to begin designing the aqueous… Expand The antithrombotic effects of YM466, a synthetic direct inhibitor of human factor Xa (FXa), were evaluated in an arterio‐venous… Expand A specific method for the determination of YM466, a novel Factor Xa inhibitor, in rat and dog plasma was developed and validated… Expand