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YM 466

Known as: YM-466, YM466 
National Institutes of Health

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YM 60828

Papers overview

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2010
2010
Pharmacokinetics of YM466, a new factor Xa inhibitor, in rats and dogs
SummaryThe pharmacokinetics of YM466, a selective inhibitor for factor Xa, was investigated after single intravenous and oral… 
2007
2007
Experimental model of lower limb ischemia in rats and the effect of YM466, an oral direct factor Xa inhibitor.
A simple, quantitative, and reproducible model of lower limb ischemia was developed. Vascular injury was induced by ferric… 
2006
2006
Hepatobiliary transport of YM466, a novel factor Xa inhibitor, in rats
SummaryYM466, a novel factor Xa inhibitor, is a hydrophilic compound with a carboxylic acid moiety. Previous studies in rats have… 
2004
2004
Combined effects of a factor Xa inhibitor YM466 and a GPIIb/IIIa antagonist YM128 on thrombosis and neointima formation in mice
Summary Thrombosis and neointima formation limit the efficacy of coronary angioplasty. Factor Xa inhibitors and GPIIb/IIIa… 
2004
2004
Absorption, distribution, metabolism and excretion of YM466, a novel factor Xa inhibitor, in rats
YM466 is a novel factor Xa inhibitor for the treatment of thrombosis. The absorption, distribution, metabolism and excretion of… 
2004
2004
A liquid chromatographic-tandem mass spectrometric method for the determination of YM466, a novel Factor Xa inhibitor, in rat plasma.
2003
2003
Potential Use of Cyclodextrins to Enhance the Solubility of YM466 in Aqueous Solution
Abstract Various solubilizing agents for YM466, a new Factor Xa inhibitor, were investigated to begin designing the aqueous… 
2003
2003
Antithrombotic effects of YM466, a synthesized direct inhibitor of factor Xa, in an arterio‐venous shunt thrombosis model in squirrel monkeys
The antithrombotic effects of YM466, a synthetic direct inhibitor of human factor Xa (FXa), were evaluated in an arterio‐venous… 
2002
2002
LC determination of YM466, a new factor Xa inhibitor, in rat and dog plasma.
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