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Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors
TLDR
It is reported that glutamate induces single-peaked intracellular Ca2+ mobilization in mGluR1α-transfected cells but elicits Ca2- oscillations in m gluR5a-expressing cells, the first evidence that PKC phosphorylation of G-protein-coupled receptors is important in producing oscillations of Ca2 + signalling.
Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics
TLDR
The present study provided integrated information about the time course of pain and other disease development parameters in the CFA-induced arthritic rats, and clarified acute efficacies of different categories of analgesics for the allodynia and hyperalgesia.
Radioligand Binding Properties and Pharmacological Characterization of 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a High-Affinity, Selective, and
TLDR
YM-298198 is a newly synthesized, high-affinity, selective, and noncompetitive antagonist of mGluR1 that will be a useful pharmacological tool due to its highly active properties in vitro and in vivo.
YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist.
TLDR
YM90K was shown to be a potent and selective antagonist for AMPA/kainate receptors in vitro and in vivo and may provide a therapeutic effect in various neurodegenerative disorders such as ischemic stroke.
In‐vitro Characterization of YM872, a Selective, Potent and Highly Water‐soluble α‐Amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate Receptor Antagonist
The in‐vitro pharmacological properties of (2,3‐dioxo‐7‐(1H‐imidazol‐***1‐yl)‐6‐nitro‐1,2,3,4‐tetrahydro‐1‐quinoxalinyl)‐acetic acid monohydrate, YM872, a novel and highly water‐soluble
The Metabotropic Glutamate Receptor mGluR5 Induces Calcium Oscillations in Cultured Astrocytes via Protein Kinase C Phosphorylation
TLDR
It is demonstrated that mGluR5 is capable of inducing [Ca2+]i oscillations in cultured astrocytes and that phosphorylation/dephosphorylation of mGlamorganic glutamate receptor is critical in [Ca1+] i oscillations, analogous to the cloned mGLUR5 expressed in heterologous cell lines.
YM872: a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist.
TLDR
The evidence for the neuroprotective efficacy of YM872 suggests its therapeutic potential in the treatment of acute stroke in humans and in rats and cats subjected to permanent occlusion of the left middle cerebral artery.
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