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YM 022

Known as: Urea, N-(2,3-dihydro-1-(2-(2-methylphenyl)-2-oxoethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-N'-(3-methylphenyl)-, (R)-, YM-022, YM022 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

BenzodiazepinesHormone Antagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Gastrin promotes intestinal polyposis through cholecystokinin-B receptor-mediated proliferative signaling and fostering tumor microenvironment.
Increased serum gastrin concentrations in patients with colorectal cancer suggested the tumorigenic trophic effect of gastrin… 
2008
2008
Hypergastrinemia increases gastric epithelial susceptibility to apoptosis
1999
1999
Pharmacological analysis of CCK2 receptor antagonists using isolated rat stomach ECL cells
Gastrin stimulates rat stomach ECL cells to secrete histamine and pacreastatin, a chromogranin A (CGA)‐derived peptide. The… 
Review
1998
Review
1998
CCK receptor antagonists.
1998
1998
Mutations within the cholecystokinin-B/gastrin receptor ligand 'pocket' interconvert the functions of nonpeptide agonists and antagonists.
We have reported previously that the transmembrane domains of the cholecystokinin-B/gastrin receptor (CCK-BR) comprise a putative… 
1996
1996
Evaluation of the specificity and potency of a series of cholecystokinin-B/gastrin receptor antagonists in vivo.
The potency and specificity of five proposed cholecystokinin-B receptor antagonists, YM022, RP73870, L-740,093, L-365,260 and… 
1996
1996
Mechanisms of action of cholecystokinin in the canine gastrointestinal tract: role of vasoactive intestinal peptide and nitric oxide.
This study defined the cholecystokinin (CCK)/gastrin receptor subtypes at which CCK octapeptide (CCK8) and gastrin 17 (G17)act on… 
1996
1996
Effect of cholecystokinin-B/gastrin receptor blockade on gastric acid secretion in conscious rats.
Gastrin, histamine and acetylcholine are physiological stimuli of gastric acid secretion. The cholecystokinin-B/gastrin receptor… 
1995
1995
Gastrin receptor antagonist YM022 prevents hypersecretion after long-term acid suppression.
Female rats were treated orally for 13 wk with YM022 (300 mumol.kg-1.day-1) and with omeprazole (400 mumol.kg-1.day-1) or… 
1994
1994
Characterization of YM022: its CCKB/gastrin receptor binding profile and antagonism to CCK-8-induced Ca2+ mobilization.
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