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YM 022

Known as: Urea, N-(2,3-dihydro-1-(2-(2-methylphenyl)-2-oxoethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-N'-(3-methylphenyl)-, (R)-, YM-022, YM022 
National Institutes of Health

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2 relations

Broader (2)

BenzodiazepinesHormone Antagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Gastrin promotes intestinal polyposis through cholecystokinin-B receptor-mediated proliferative signaling and fostering tumor microenvironment.
Increased serum gastrin concentrations in patients with colorectal cancer suggested the tumorigenic trophic effect of gastrin… 
2008
2008
Hypergastrinemia increases gastric epithelial susceptibility to apoptosis
2001
2001
Effects of CCK2 receptor blockade on growth parameters in gastrointestinal tract and pancreas in rats.
Gastrin has a growth-promoting effect on the oxyntic mucosa of the stomach but has been claimed also to affect other parts of the… 
1999
1999
Pharmacological analysis of CCK2 receptor antagonists using isolated rat stomach ECL cells
Gastrin stimulates rat stomach ECL cells to secrete histamine and pacreastatin, a chromogranin A (CGA)‐derived peptide. The… 
1997
1997
Cholecystokinin-B/gastrin receptor blockade suppresses the activity of rat stomach ECL cells.
Gastrin controls the histamine- and chromogranin A-producing enterochromaffin-like (ECL) cells, the predominant endocrine cell… 
1997
1997
YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl]-3-(3-methylphenyl)urea]: an irreversible cholecystokinin type-B receptor antagonist.
1996
1996
Evaluation of the specificity and potency of a series of cholecystokinin-B/gastrin receptor antagonists in vivo.
The potency and specificity of five proposed cholecystokinin-B receptor antagonists, YM022, RP73870, L-740,093, L-365,260 and… 
1996
1996
Effect of cholecystokinin-B/gastrin receptor blockade on gastric acid secretion in conscious rats.
Gastrin, histamine and acetylcholine are physiological stimuli of gastric acid secretion. The cholecystokinin-B/gastrin receptor… 
1995
1995
Gastrin receptor antagonist YM022 prevents hypersecretion after long-term acid suppression.
Female rats were treated orally for 13 wk with YM022 (300 mumol.kg-1.day-1) and with omeprazole (400 mumol.kg-1.day-1) or… 
1995
1995
New 1,4-benzodiazepin-2-one derivatives as gastrin/cholecystokinin-B antagonists.
A novel series of 1-aroylmethyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one derivatives was prepared and evaluated for activity as… 
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